Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study

Correlation between corneal innervation and inflammation evaluated with confocal microscopy and... Graefes Arch Clin Exp Ophthalmol (2017) 255:1771–1778 DOI 10.1007/s00417-017-3680-3 CORNEA Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study 1,3 2 1,3 1,3 Tudor C. Tepelus & Gloria B. Chiu & Jianyan Huang & Ping Huang & 1,3 3 1,3 SriniVas R. Sadda & John Irvine & Olivia L. Lee Received: 18 January 2017 /Revised: 2 April 2017 /Accepted: 18 April 2017 /Published online: 20 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract group, 40.33 ± 31.63 cells/mm in the NSDE group and Purpose To evaluate corneal innervation and inflammatory 27.53 ± 5.58 cells/mm in the control group (P <0.05, cell infiltration using in vivo confocal microscopy (IVCM) ANOVA). In comparison to the control group, the density of and to correlate these findings with subjective symptoms of DCs was increased in the SSDE (P < 0.001) and the NSDE dry eye, as measured by the Ocular Surface Disease Index groups (P = 0.07). Significant correlations were found be- (OSDI) in patients with non-Sjögren’s (NSDE) and tween the nerve density and DC density (r = −0.57, Sjögren’s syndrome dry eyes (SSDE). P < 0.001), between the nerve density and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Graefe's Archive for Clinical and Experimental Ophthalmology Springer Journals

Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Ophthalmology
ISSN
0721-832X
eISSN
1435-702X
D.O.I.
10.1007/s00417-017-3680-3
Publisher site
See Article on Publisher Site

Abstract

Graefes Arch Clin Exp Ophthalmol (2017) 255:1771–1778 DOI 10.1007/s00417-017-3680-3 CORNEA Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study 1,3 2 1,3 1,3 Tudor C. Tepelus & Gloria B. Chiu & Jianyan Huang & Ping Huang & 1,3 3 1,3 SriniVas R. Sadda & John Irvine & Olivia L. Lee Received: 18 January 2017 /Revised: 2 April 2017 /Accepted: 18 April 2017 /Published online: 20 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract group, 40.33 ± 31.63 cells/mm in the NSDE group and Purpose To evaluate corneal innervation and inflammatory 27.53 ± 5.58 cells/mm in the control group (P <0.05, cell infiltration using in vivo confocal microscopy (IVCM) ANOVA). In comparison to the control group, the density of and to correlate these findings with subjective symptoms of DCs was increased in the SSDE (P < 0.001) and the NSDE dry eye, as measured by the Ocular Surface Disease Index groups (P = 0.07). Significant correlations were found be- (OSDI) in patients with non-Sjögren’s (NSDE) and tween the nerve density and DC density (r = −0.57, Sjögren’s syndrome dry eyes (SSDE). P < 0.001), between the nerve density and

Journal

Graefe's Archive for Clinical and Experimental OphthalmologySpringer Journals

Published: May 20, 2017

References

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