Graefes Arch Clin Exp Ophthalmol (2017) 255:1771–1778 DOI 10.1007/s00417-017-3680-3 CORNEA Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study 1,3 2 1,3 1,3 Tudor C. Tepelus & Gloria B. Chiu & Jianyan Huang & Ping Huang & 1,3 3 1,3 SriniVas R. Sadda & John Irvine & Olivia L. Lee Received: 18 January 2017 /Revised: 2 April 2017 /Accepted: 18 April 2017 /Published online: 20 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract group, 40.33 ± 31.63 cells/mm in the NSDE group and Purpose To evaluate corneal innervation and inflammatory 27.53 ± 5.58 cells/mm in the control group (P <0.05, cell infiltration using in vivo confocal microscopy (IVCM) ANOVA). In comparison to the control group, the density of and to correlate these findings with subjective symptoms of DCs was increased in the SSDE (P < 0.001) and the NSDE dry eye, as measured by the Ocular Surface Disease Index groups (P = 0.07). Significant correlations were found be- (OSDI) in patients with non-Sjögren’s (NSDE) and tween the nerve density and DC density (r = −0.57, Sjögren’s syndrome dry eyes (SSDE). P < 0.001), between the nerve density and
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: May 20, 2017
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