Copper(II) acetate monohydrate: an efficient and eco-friendly catalyst for the one-pot multi-component synthesis of biologically active spiropyrans and 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives under solvent-free conditions

Copper(II) acetate monohydrate: an efficient and eco-friendly catalyst for the one-pot... H N NC O O or Cu (OAC) .H O (15mol%) 2 2 + NC CN or + H N Solvent free, 80°C O NC H N O NH NH .H O 2 2 2 + O Ar Cu(OAC) .H O (20 mol %) 2 2 CN CN Solvent free, 80 °C NH Ar CHO + O CN & Malek Taher Maghsoodlou mt_maghsoodlou@yahoo.com; mt_maghsoodlou@chem.usb.ac.ir Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran Faculty of Science, Velayat University, Iranshahr, Iran 123 7842 F. Mohamadpour et al. Keywords Copper(II) acetate monohydrate  Spiro-4H-pyran derivatives  1H- pyrazolo[1,2-b]phthalazine-5,10-dione derivatives  Solvent-free conditions Introduction Nowadays, most research has been focused on the study of synthesising heterocyclic compounds. Organic compounds containing nitrogen heterocyclic rings are important compounds in medicinal chemistry. The synthesis of biologically active spiropyran derivatives (spirooxindole) and 1H-pyrazolo[1,2-b]phthalazine-5,10-dione deriva- tives have been given much attention because of their advantages in various biological (Figs. 1, 2) and pharmaceutical fields, for example, as anti-HIV [1], anti-tubercular [2], fungicidal [3], anticonvulsant [4] and anticancer [5, 6] agents; in addition, these spirocycles are MDM2 inhibitors [7] and progesterone receptor modulators [8]. In recent decades, a number of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Copper(II) acetate monohydrate: an efficient and eco-friendly catalyst for the one-pot multi-component synthesis of biologically active spiropyrans and 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives under solvent-free conditions

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2565-0
Publisher site
See Article on Publisher Site

Abstract

H N NC O O or Cu (OAC) .H O (15mol%) 2 2 + NC CN or + H N Solvent free, 80°C O NC H N O NH NH .H O 2 2 2 + O Ar Cu(OAC) .H O (20 mol %) 2 2 CN CN Solvent free, 80 °C NH Ar CHO + O CN & Malek Taher Maghsoodlou mt_maghsoodlou@yahoo.com; mt_maghsoodlou@chem.usb.ac.ir Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran Faculty of Science, Velayat University, Iranshahr, Iran 123 7842 F. Mohamadpour et al. Keywords Copper(II) acetate monohydrate  Spiro-4H-pyran derivatives  1H- pyrazolo[1,2-b]phthalazine-5,10-dione derivatives  Solvent-free conditions Introduction Nowadays, most research has been focused on the study of synthesising heterocyclic compounds. Organic compounds containing nitrogen heterocyclic rings are important compounds in medicinal chemistry. The synthesis of biologically active spiropyran derivatives (spirooxindole) and 1H-pyrazolo[1,2-b]phthalazine-5,10-dione deriva- tives have been given much attention because of their advantages in various biological (Figs. 1, 2) and pharmaceutical fields, for example, as anti-HIV [1], anti-tubercular [2], fungicidal [3], anticonvulsant [4] and anticancer [5, 6] agents; in addition, these spirocycles are MDM2 inhibitors [7] and progesterone receptor modulators [8]. In recent decades, a number of

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 30, 2016

References

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