Keywords CuBr 2-Aminobenzohydrazide Ullmann reaction Thienopyrazoloquinazolinone Introduction Quinazoline is a fused bicyclic heterocycle containing two nitrogen atoms, and some of its derivatives possess good antitumor activities [1–4]. A well-known example is geﬁtinib, a poly-substituted quinazoline on the market since 2005 as a good clinical drug to treat lung cancer unsuitable for chemical treatment . It is reported that pyrazoloquinazoline derivatives are also an important class of & Xiang-Shan Wang email@example.com School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou 221116, Jiangsu, People’s Republic of China 123 6770 W.-T. Zhang et al. potentially active compounds possessing signiﬁcant pharmacological and biological activities, such as antibacterial , antagonistic , antifungal , antiinﬂammatory , and antiallergic actions . In addition, some of them are used as a wide range of inhibitors, for example, topoisomerase I inhibitor , MPS1 inhibitor , phosphodiesterase 10A inhibitor , PDK1 inhibitor , and tyrosine kinase inhibitor . Thieno- quinazoline is a very unusual heterocyclic skeleton, with only two reports regarding its synthesis and applications: as Eph inhibitor  and antitumor reagent . Therefore, design of novel methods for synthesis of these bioactive skeletons is of great
Research on Chemical Intermediates – Springer Journals
Published: Mar 7, 2016
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