Copper(I)-catalyzed synthesis of thienopyrazoloquinazolinone derivatives under ligand-free conditions

Copper(I)-catalyzed synthesis of thienopyrazoloquinazolinone derivatives under ligand-free... Keywords CuBr  2-Aminobenzohydrazide  Ullmann reaction Thienopyrazoloquinazolinone Introduction Quinazoline is a fused bicyclic heterocycle containing two nitrogen atoms, and some of its derivatives possess good antitumor activities [1–4]. A well-known example is gefitinib, a poly-substituted quinazoline on the market since 2005 as a good clinical drug to treat lung cancer unsuitable for chemical treatment [5]. It is reported that pyrazoloquinazoline derivatives are also an important class of & Xiang-Shan Wang School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou 221116, Jiangsu, People’s Republic of China 123 6770 W.-T. Zhang et al. potentially active compounds possessing significant pharmacological and biological activities, such as antibacterial [6], antagonistic [7], antifungal [8], antiinflammatory [9], and antiallergic actions [10]. In addition, some of them are used as a wide range of inhibitors, for example, topoisomerase I inhibitor [11], MPS1 inhibitor [12], phosphodiesterase 10A inhibitor [13], PDK1 inhibitor [14], and tyrosine kinase inhibitor [15]. Thieno- quinazoline is a very unusual heterocyclic skeleton, with only two reports regarding its synthesis and applications: as Eph inhibitor [16] and antitumor reagent [17]. Therefore, design of novel methods for synthesis of these bioactive skeletons is of great Research on Chemical Intermediates Springer Journals

Copper(I)-catalyzed synthesis of thienopyrazoloquinazolinone derivatives under ligand-free conditions

Loading next page...
Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial