Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2904-9) contains supplementary material, which is available to authorized users. & Abbas Ali Esmaeili email@example.com Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran Department of Chemistry, Tulane University, New Orleans, LA, USA 123 4684 M. Akhavan et al. Keywords Multicomponent reaction Dialkylacetylenedicarboxylates Pyrano[23- d]thiadiazolo[32-a]pyrimidine Alkyl isocyanide 7-Hydroxy-2-phenyl-5H- thiadiazolo[32-a]pyrimidine-5-one Introduction Fused heterocyclic compounds are ever-present in natural products and medicinal chemistry [1–7]. They are signiﬁcant synthetic targets for synthetic chemists due to their great potential as sources of noble functional compounds. Angularly fused polyheterocyles have particularly turned out to be appealing targets among synthetic chemists [8–14]. Thiadiazolopyrimidines have been broadly appealing to medicinal chemists due to their varying pharmacological properties including anti-tumor [15, 16], anti- allergy , anti-bacterial , fungicidal , anti-viral , and herbicidal activities . Moreover, a series of thiadizolopyrimidine derivatives have been assessed for their powerful neuraminidase inhibitory activity , carbon anhydrase inhibitory activity , and RNA synthesis inhibitory activity  (Fig. 1). On the other hand, pyrans fused with other cyclic molecules are plentiful in various natural and bioactive synthetic products [25–30]. For example, pyranopy- rimidines have appeared as a potentially appealing
Research on Chemical Intermediates – Springer Journals
Published: Feb 17, 2017
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