Convenient one-pot access to novel densely functionalized pyrano[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidines via three component reaction

Convenient one-pot access to novel densely functionalized... Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2904-9) contains supplementary material, which is available to authorized users. & Abbas Ali Esmaeili abesmaeili@um.ac.ir Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran Department of Chemistry, Tulane University, New Orleans, LA, USA 123 4684 M. Akhavan et al. Keywords Multicomponent reaction  Dialkylacetylenedicarboxylates  Pyrano[23- d][134]thiadiazolo[32-a]pyrimidine  Alkyl isocyanide  7-Hydroxy-2-phenyl-5H- [134]thiadiazolo[32-a]pyrimidine-5-one Introduction Fused heterocyclic compounds are ever-present in natural products and medicinal chemistry [1–7]. They are significant synthetic targets for synthetic chemists due to their great potential as sources of noble functional compounds. Angularly fused polyheterocyles have particularly turned out to be appealing targets among synthetic chemists [8–14]. Thiadiazolopyrimidines have been broadly appealing to medicinal chemists due to their varying pharmacological properties including anti-tumor [15, 16], anti- allergy [17], anti-bacterial [18], fungicidal [19], anti-viral [20], and herbicidal activities [21]. Moreover, a series of thiadizolopyrimidine derivatives have been assessed for their powerful neuraminidase inhibitory activity [22], carbon anhydrase inhibitory activity [23], and RNA synthesis inhibitory activity [24] (Fig. 1). On the other hand, pyrans fused with other cyclic molecules are plentiful in various natural and bioactive synthetic products [25–30]. For example, pyranopy- rimidines have appeared as a potentially appealing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Convenient one-pot access to novel densely functionalized pyrano[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidines via three component reaction

Loading next page...
 
/lp/springer_journal/convenient-one-pot-access-to-novel-densely-functionalized-pyrano-2-3-d-c5hRjE9dGS
Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2904-9
Publisher site
See Article on Publisher Site

Abstract

Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2904-9) contains supplementary material, which is available to authorized users. & Abbas Ali Esmaeili abesmaeili@um.ac.ir Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran Department of Chemistry, Tulane University, New Orleans, LA, USA 123 4684 M. Akhavan et al. Keywords Multicomponent reaction  Dialkylacetylenedicarboxylates  Pyrano[23- d][134]thiadiazolo[32-a]pyrimidine  Alkyl isocyanide  7-Hydroxy-2-phenyl-5H- [134]thiadiazolo[32-a]pyrimidine-5-one Introduction Fused heterocyclic compounds are ever-present in natural products and medicinal chemistry [1–7]. They are significant synthetic targets for synthetic chemists due to their great potential as sources of noble functional compounds. Angularly fused polyheterocyles have particularly turned out to be appealing targets among synthetic chemists [8–14]. Thiadiazolopyrimidines have been broadly appealing to medicinal chemists due to their varying pharmacological properties including anti-tumor [15, 16], anti- allergy [17], anti-bacterial [18], fungicidal [19], anti-viral [20], and herbicidal activities [21]. Moreover, a series of thiadizolopyrimidine derivatives have been assessed for their powerful neuraminidase inhibitory activity [22], carbon anhydrase inhibitory activity [23], and RNA synthesis inhibitory activity [24] (Fig. 1). On the other hand, pyrans fused with other cyclic molecules are plentiful in various natural and bioactive synthetic products [25–30]. For example, pyranopy- rimidines have appeared as a potentially appealing

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Feb 17, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off