Convenient one-pot access to novel densely functionalized pyrano[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidines via three component reaction

Convenient one-pot access to novel densely functionalized... Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2904-9) contains supplementary material, which is available to authorized users. & Abbas Ali Esmaeili abesmaeili@um.ac.ir Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran Department of Chemistry, Tulane University, New Orleans, LA, USA 123 4684 M. Akhavan et al. Keywords Multicomponent reaction  Dialkylacetylenedicarboxylates  Pyrano[23- d][134]thiadiazolo[32-a]pyrimidine  Alkyl isocyanide  7-Hydroxy-2-phenyl-5H- [134]thiadiazolo[32-a]pyrimidine-5-one Introduction Fused heterocyclic compounds are ever-present in natural products and medicinal chemistry [1–7]. They are significant synthetic targets for synthetic chemists due to their great potential as sources of noble functional compounds. Angularly fused polyheterocyles have particularly turned out to be appealing targets among synthetic chemists [8–14]. Thiadiazolopyrimidines have been broadly appealing to medicinal chemists due to their varying pharmacological properties including anti-tumor [15, 16], anti- allergy [17], anti-bacterial [18], fungicidal [19], anti-viral [20], and herbicidal activities [21]. Moreover, a series of thiadizolopyrimidine derivatives have been assessed for their powerful neuraminidase inhibitory activity [22], carbon anhydrase inhibitory activity [23], and RNA synthesis inhibitory activity [24] (Fig. 1). On the other hand, pyrans fused with other cyclic molecules are plentiful in various natural and bioactive synthetic products [25–30]. For example, pyranopy- rimidines have appeared as a potentially appealing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Convenient one-pot access to novel densely functionalized pyrano[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidines via three component reaction

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2904-9
Publisher site
See Article on Publisher Site

Abstract

Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2904-9) contains supplementary material, which is available to authorized users. & Abbas Ali Esmaeili abesmaeili@um.ac.ir Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran Department of Chemistry, Tulane University, New Orleans, LA, USA 123 4684 M. Akhavan et al. Keywords Multicomponent reaction  Dialkylacetylenedicarboxylates  Pyrano[23- d][134]thiadiazolo[32-a]pyrimidine  Alkyl isocyanide  7-Hydroxy-2-phenyl-5H- [134]thiadiazolo[32-a]pyrimidine-5-one Introduction Fused heterocyclic compounds are ever-present in natural products and medicinal chemistry [1–7]. They are significant synthetic targets for synthetic chemists due to their great potential as sources of noble functional compounds. Angularly fused polyheterocyles have particularly turned out to be appealing targets among synthetic chemists [8–14]. Thiadiazolopyrimidines have been broadly appealing to medicinal chemists due to their varying pharmacological properties including anti-tumor [15, 16], anti- allergy [17], anti-bacterial [18], fungicidal [19], anti-viral [20], and herbicidal activities [21]. Moreover, a series of thiadizolopyrimidine derivatives have been assessed for their powerful neuraminidase inhibitory activity [22], carbon anhydrase inhibitory activity [23], and RNA synthesis inhibitory activity [24] (Fig. 1). On the other hand, pyrans fused with other cyclic molecules are plentiful in various natural and bioactive synthetic products [25–30]. For example, pyranopy- rimidines have appeared as a potentially appealing

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Feb 17, 2017

References

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