Peroxisomes are important organelles that have diverse metabolic functions and participate in the pathogenicity of fungal pathogens. Previous studies indicate that most functions of peroxisomes are dependent on peroxisomal matrix proteins, which are delivered from the cytoplasm into peroxisomes by peroxisomal protein importers. In this study, the roles of peroxisomal protein importer AflPex5 were investigated in Aspergillus flavus with the application of gene disruption. AflPex5 deletion mutants failed to localize the fluorescently fused peroxisomal targeting signal 1 (PTS1) proteins to peroxisomes. Deletion of AflPex5 caused defects in sporulation, sclerotial formation, aflatoxin biosynthesis, stress response, and plant infection. Moreover, AflPex5 null mutants exhibited a significant defect in carbon metabolism and oxidants’ clearance. These results indicate that the PTS1 pathway mediated by AflPex5 serves as an important role in the development, metabolism, and patho- genesis of A. flavus. Keywords Peroxisome · Pex5 · Aspergillus flavus · Aflatoxins · Pathogenesis Introduction Aitchison 2013; Waterham et al. 2016). Plant peroxisomes play a crucial role in numerous processes, including pho- Peroxisomes are almost essential organelles found in torespiration, development, and responses to abiotic and nearly all eukaryotes (Gabaldón 2010). These organelles biotic stress (Hu et al. 2012). Peroxisomes also harbor mul- are involved in a variety of metabolic functions that
Current Genetics – Springer Journals
Published: Jun 5, 2018
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