Contrast-enhanced ultrasonography in chronic glomerulonephritides: correlation with histological parameters of disease activity

Contrast-enhanced ultrasonography in chronic glomerulonephritides: correlation with histological... Purpose To compare contrast-enhanced ultrasonography (CEUS)-derived time-intensity (TI) curves with histological find - ings in kidneys of patients affected by chronic glomerulonephritides (GN) in the early stage of disease. Methods Research ethics committee approval and patient written informed consent were obtained. Thirty-one patients who showed clinical and laboratory signs of GN, with preserved renal function, were consecutively enrolled. They underwent kidney CEUS, from which TI curves were obtained, and kidney biopsy. TI curves were compared with clinical data, ultra- sound (US) Doppler, and histological parameters. Results The persistence of contrast agent signal during the wash-out phase was found to be correlated with the degree of disease activity (p = 0.016) and in particular with the presence of mesangial hyperplasia (p = 0.008). No correlation was observed between TI curves and clinical or Doppler US-derived parameters. Conclusions The persistence of contrast agent signal in the wash-out phase of CEUS appears to reflect a disturbance of perfusion in glomerular capillaries in the early stages of GN. We found that the histological element directly correlated with the prolonged wash-out was mesangial hyperplasia. Keywords CEUS · Kidney · Glomerulonephritis · Nephropathy · Ultrasonography Sommario Scopo Confrontare le curve intensità-tempo (TI) derivate dallo studio ecografico con mezzo di http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Ultrasound Springer Journals

Contrast-enhanced ultrasonography in chronic glomerulonephritides: correlation with histological parameters of disease activity

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB)
Subject
Medicine & Public Health; Ultrasound
eISSN
1876-7931
D.O.I.
10.1007/s40477-018-0298-1
Publisher site
See Article on Publisher Site

Abstract

Purpose To compare contrast-enhanced ultrasonography (CEUS)-derived time-intensity (TI) curves with histological find - ings in kidneys of patients affected by chronic glomerulonephritides (GN) in the early stage of disease. Methods Research ethics committee approval and patient written informed consent were obtained. Thirty-one patients who showed clinical and laboratory signs of GN, with preserved renal function, were consecutively enrolled. They underwent kidney CEUS, from which TI curves were obtained, and kidney biopsy. TI curves were compared with clinical data, ultra- sound (US) Doppler, and histological parameters. Results The persistence of contrast agent signal during the wash-out phase was found to be correlated with the degree of disease activity (p = 0.016) and in particular with the presence of mesangial hyperplasia (p = 0.008). No correlation was observed between TI curves and clinical or Doppler US-derived parameters. Conclusions The persistence of contrast agent signal in the wash-out phase of CEUS appears to reflect a disturbance of perfusion in glomerular capillaries in the early stages of GN. We found that the histological element directly correlated with the prolonged wash-out was mesangial hyperplasia. Keywords CEUS · Kidney · Glomerulonephritis · Nephropathy · Ultrasonography Sommario Scopo Confrontare le curve intensità-tempo (TI) derivate dallo studio ecografico con mezzo di

Journal

Journal of UltrasoundSpringer Journals

Published: Apr 24, 2018

References

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