Contamination of live attenuated vaccines with an infectious feline endogenous retrovirus (RD-114 virus)

Contamination of live attenuated vaccines with an infectious feline endogenous retrovirus (RD-114... Retroviruses are classified as exogenous and endogenous retroviruses according to the mode of transmission. Endogenous retroviruses (ERVs) are retroviruses which have been integrated into germ-line cells and inherited from parents to offspring. Most ERVs are inactivated by deletions and mutations; however, certain ERVs maintain their infectivity and infect the same host and new hosts as exogenous retroviruses. All domestic cats have infectious ERVs, termed RD-114 virus. Several canine and feline attenuated vaccines are manufactured using RD-114 virus-producing cell lines such as Crandell-Rees feline kidney cells; therefore, it is possible that infectious RD-114 virus contaminates live attenuated vaccines. Recently, Japanese and UK research groups found that several feline and canine vaccines were indeed contaminated with infectious RD-114 virus. This was the first incidence of contamination of ‘infectious’ ERVs in live attenuated vaccines. RD-114 virus replicates efficiently in canine cell lines and primary cells. Therefore, it is possible that RD-114 virus infects dogs following inoculation with contaminated vaccines and induces proliferative diseases and immune suppression, if it adapts to grow efficiently in dogs. In this review, we summarize the incidence of contamination of RD-114 virus in live attenuated vaccines and potential risks of infection with RD-114 virus in dogs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Contamination of live attenuated vaccines with an infectious feline endogenous retrovirus (RD-114 virus)

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1809-1
Publisher site
See Article on Publisher Site

Abstract

Retroviruses are classified as exogenous and endogenous retroviruses according to the mode of transmission. Endogenous retroviruses (ERVs) are retroviruses which have been integrated into germ-line cells and inherited from parents to offspring. Most ERVs are inactivated by deletions and mutations; however, certain ERVs maintain their infectivity and infect the same host and new hosts as exogenous retroviruses. All domestic cats have infectious ERVs, termed RD-114 virus. Several canine and feline attenuated vaccines are manufactured using RD-114 virus-producing cell lines such as Crandell-Rees feline kidney cells; therefore, it is possible that infectious RD-114 virus contaminates live attenuated vaccines. Recently, Japanese and UK research groups found that several feline and canine vaccines were indeed contaminated with infectious RD-114 virus. This was the first incidence of contamination of ‘infectious’ ERVs in live attenuated vaccines. RD-114 virus replicates efficiently in canine cell lines and primary cells. Therefore, it is possible that RD-114 virus infects dogs following inoculation with contaminated vaccines and induces proliferative diseases and immune suppression, if it adapts to grow efficiently in dogs. In this review, we summarize the incidence of contamination of RD-114 virus in live attenuated vaccines and potential risks of infection with RD-114 virus in dogs.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2014

References

  • Biodistribution of the RD114/mammalian type D retrovirus receptor, RDR
    Green, BJ; Lee, CS; Rasko, JE
  • The evolution, distribution and diversity of endogenous retroviruses
    Gifford, R; Tristem, M
  • Infection of human cells by an endogenous retrovirus of pigs
    Patience, C; Takeuchi, Y; Weiss, RA
  • Sequence comparison of three infectious molecular clones of RD-114 virus
    Shimode, S; Yoshikawa, R; Hoshino, S; Nakaya, Y; Sakaguchi, S; Kobayashi, T; Miyazawa, T
  • Resurrection of endogenous retroviruses in antibody-deficient mice
    Young, GR; Eksmond, U; Salcedo, R; Alexopoulou, L; Stoye, JP; Kassiotis, G

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