Consider potential drug interactions when starting combination therapy with antiepileptic drugs

Consider potential drug interactions when starting combination therapy with antiepileptic drugs Alternative monotherapy and adjunctive therapy are both valid options following failure of initial monotherapy with an antiepileptic drug (AED). Depending on the cause of initial failure of AED monotherapy, one option may be favoured over the other. When proceeding with adjunctive therapy, considerations should include choosing an agent with a different mechanism of action to that of the existing antiepileptic drug and avoiding unfavourable pharmacokinetic interactions (e.g. those related to hepatic metabolism and enzyme induction). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drugs & Therapy Perspectives Springer Journals

Consider potential drug interactions when starting combination therapy with antiepileptic drugs

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Pharmacy; Pharmacy; Pharmacotherapy
ISSN
1172-0360
eISSN
1179-1977
D.O.I.
10.1007/s40267-018-0525-z
Publisher site
See Article on Publisher Site

Abstract

Alternative monotherapy and adjunctive therapy are both valid options following failure of initial monotherapy with an antiepileptic drug (AED). Depending on the cause of initial failure of AED monotherapy, one option may be favoured over the other. When proceeding with adjunctive therapy, considerations should include choosing an agent with a different mechanism of action to that of the existing antiepileptic drug and avoiding unfavourable pharmacokinetic interactions (e.g. those related to hepatic metabolism and enzyme induction).

Journal

Drugs & Therapy PerspectivesSpringer Journals

Published: May 29, 2018

References

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