Consider potential drug interactions when starting combination therapy with antiepileptic drugs

Consider potential drug interactions when starting combination therapy with antiepileptic drugs Drugs Ther Perspect https://doi.org/10.1007/s40267-018-0525-z DR UG REA C TIO N S A ND INTERA C TION S Consider potential drug interactions when starting combination therapy with antiepileptic drugs Adis Medical Writers Springer International Publishing AG, part of Springer Nature 2018 Abstract Alternative monotherapy and adjunctive therapy Choose the next step based on the cause of failure are both valid options following failure of initial monotherapy with an antiepileptic drug (AED). Depending Alternative monotherapy is the preferred next step in cases on the cause of initial failure of AED monotherapy, one of idiosyncratic toxicity, or lack of tolerability at low option may be favoured over the other. When proceeding dosages of the initial AED [1]. Other situations that can with adjunctive therapy, considerations should include favour alternative monotherapy include compliance chal- choosing an agent with a different mechanism of action to lenges and the need to limit the number of drugs taken (e.g. that of the existing antiepileptic drug and avoiding unfa- for reasons such as pregnancy, polypharmacy or financial vourable pharmacokinetic interactions (e.g. those related to limitations) [1]. hepatic metabolism and enzyme induction). There is no clear consensus on the preferred approach when initial monotherapy fails because of lack http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drugs & Therapy Perspectives Springer Journals

Consider potential drug interactions when starting combination therapy with antiepileptic drugs

Drugs & Therapy Perspectives , Volume OnlineFirst – May 29, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Pharmacy; Pharmacy; Pharmacotherapy
ISSN
1172-0360
eISSN
1179-1977
D.O.I.
10.1007/s40267-018-0525-z
Publisher site
See Article on Publisher Site

Abstract

Drugs Ther Perspect https://doi.org/10.1007/s40267-018-0525-z DR UG REA C TIO N S A ND INTERA C TION S Consider potential drug interactions when starting combination therapy with antiepileptic drugs Adis Medical Writers Springer International Publishing AG, part of Springer Nature 2018 Abstract Alternative monotherapy and adjunctive therapy Choose the next step based on the cause of failure are both valid options following failure of initial monotherapy with an antiepileptic drug (AED). Depending Alternative monotherapy is the preferred next step in cases on the cause of initial failure of AED monotherapy, one of idiosyncratic toxicity, or lack of tolerability at low option may be favoured over the other. When proceeding dosages of the initial AED [1]. Other situations that can with adjunctive therapy, considerations should include favour alternative monotherapy include compliance chal- choosing an agent with a different mechanism of action to lenges and the need to limit the number of drugs taken (e.g. that of the existing antiepileptic drug and avoiding unfa- for reasons such as pregnancy, polypharmacy or financial vourable pharmacokinetic interactions (e.g. those related to limitations) [1]. hepatic metabolism and enzyme induction). There is no clear consensus on the preferred approach when initial monotherapy fails because of lack

Journal

Drugs & Therapy PerspectivesSpringer Journals

Published: May 29, 2018

References

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