Mammalian Genome 11, 466–468 (2000). Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals 1 3,4 5 5 1,2 Cheng-Chun Wang, Thomas Brodnicki, Neal G. Copeland, Nancy A. Jenkins, Richard P. Harvey Victor Chang Cardiac Research Institute, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst 2010, Australia University of New South Wales, Faculties of Medicine and Life Sciences, Kensington 2052, Australia Genetics and Bioinformatics Group, Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Parkville 3050, Australia Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Richmond 3121, Australia Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA Received: 22 November 1999 / Accepted: 8 February 2000 Homeobox genes of the NK-2 class play essential roles in embry- peptide motif conserved at the C-terminus of the “cardiac” group onic patterning and organogenesis in vertebrates and invertebrates of NK-2 genes. An additional feature of Nkx2-4 is the presence of (Harvey 1996). Phylogenetic analysis has revealed a conserved a stretch of 16 alanines N-terminal to the homeodomain. A similar clade of mammalian NK-2 homeobox genes related to
Mammalian Genome – Springer Journals
Published: Feb 5, 2014
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