Conservative E(y)2/Sus1 protein is the member of SAGA complex and new nuclear pore-associated complex in Drosophila

Conservative E(y)2/Sus1 protein is the member of SAGA complex and new nuclear pore-associated... The SGA/TFC complex plays an important role in the regulation of transcription. We have examined the significance of the gene positioning in the nucleus for its transcription and subsequent export of nascent mRNA. It was demonstrated that E(y)2 protein was a subunit of the SAGA/TFTC histone acetyl transferase complex in Drosophila and that E(y)2 concentrated at the nuclear periphery. An interaction between E(y)2 and the nuclear pore complex (NPC) was demonstrated, as well as that SAGA/TFTC also contacted the NPC at nuclear periphery. In addition, it was shown that NPC formed complex with the Xmas-2 protein (X-linked male sterile 2) both in normal conditions and after heat shock. Importantly, the E(y)2 and Xmas-2 knockdown decreased the contact between the heat-shock protein 70 (hsp70) gene loci and the nuclear envelope before and after activation, which interfered with the transcription. Thus, E(y)2 and Xmas-2 together with SAGA/TFTC functioned in the anchoring of a subset of transcription sites to the NPCs to achieve efficient transcription and mRNA export. Russian Journal of Genetics Springer Journals

Conservative E(y)2/Sus1 protein is the member of SAGA complex and new nuclear pore-associated complex in Drosophila

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SP MAIK Nauka/Interperiodica
Copyright © 2009 by Pleiades Publishing, Ltd.
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
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