Conservation of the MC domains in eukaryotic release factor eRF3

Conservation of the MC domains in eukaryotic release factor eRF3 Eukaryotic translation termination employs two protein factors, eRF1 and eRF3. Proteins of the eRF3 family each consist of three domains. The N and M domains vary in different species, while the C domains are highly homologous. The MC domains of Homo sapiens eRF3a (hGSPT1), Xenopus laevis eRF3 (XSup35), and Mus musculus eRF3a (mGSPT1) and eRF3b (mGSPT2) were found to compensate for the sup35-21(ts) temperature-sensitive mutation and lethal disruption of the SUP35 gene in yeast Saccharomyces cerevisiae. At the same time, strains containing the MC domains of the eRF3 proteins from different species differed in growth rate and the efficiency of translation termination. Russian Journal of Genetics Springer Journals

Conservation of the MC domains in eukaryotic release factor eRF3

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Copyright © 2007 by Pleiades Publishing, Inc.
Biomedicine; Human Genetics; Microbial Genetics and Genomics; Animal Genetics and Genomics
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