Mammalian Genome 10, 530–531 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Conservation of the linkage of the murine Itga2b and Itgb3 loci in mouse Chromosome 11 1 2 3 4 Young S. Chang, Michael F. Seldin, Laurence A. Fitzgerald, Peter A. Lalley SC Genome Research, 30091 Mayfair Rd., Farmington Hills, Michigan 48331, USA Rowe Program in Genetics, Departments of Biological Chemistry and Medicine, University of California, Davis, California 95616, USA Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA Center for Baccalaureate and Graduate Studies, Rochester Institute of Technology, Rochester, New York, 14623-0887, USA Received: 11 November 1998 / Accepted: 4 January 1999 Glycoproteins GPIIb and GPIIIa are the most abundant platelet glycoproteins. The GPIIb/IIIa complex plays a primary role in platelet aggregation. Monoclonal antibodies to GPIIb/GPIIIa block aggregation, and Glanzmann’s thrombasthenic platelets lacking these Gps do not aggregate (Kunicki and Newman 1992). Mature GPIIIa (b subunit) is approximately 90 kDa in size, and GPIIb (a subunit) is approximately 145 kDa in size and contains nine sulfide bonds evenly spaced throughout its length. In addition, GPIIb and GPIIIa were designated as members of the integrin family (Hynes 1992). The family consists
Mammalian Genome – Springer Journals
Published: May 1, 1999
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