Access the full text.
Sign up today, get DeepDyve free for 14 days.
V. Albanèse, S. Holbert, C. Saada, S. Meier-Ewert, A. Lèbre, S. Morinière, L. Bougueleret, I. Gall, J. Weissenbach, G. Lennon, H. Lehrach, D. Cohen, H. Cann, C. Néri (1998)
CAG/CTG and CGG/GCC repeats in human brain reference cDNAs: outcome in searching for new dynamic mutations.Genomics, 47 3
D. Chambers, C. Abbott (1996)
Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains.Genome research, 6 8
S. Altschul, W. Gish, W. Miller, E. Myers, D. Lipman (1990)
Basic local alignment search tool.Journal of molecular biology, 215 3
N. Heintz, H. Zoghbi (2000)
Insights from mouse models into the molecular basis of neurodegeneration.Annual review of physiology, 62
G. Tóth, Zoltán Gáspári, J. Jurka (2000)
Microsatellites in different eukaryotic genomes: survey and analysis.Genome research, 10 7
Shihua Li, M. McInnis, R. Margolis, S. Antonarakis, C. Ross (1993)
Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms.Genomics, 16 3
M. Frontali, A. Novelletto, G. Annesi, C. Jodice (1999)
CAG repeat instability, cryptic sequence variation and pathogeneticity: evidence from different loci.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 354 1386
R. Stallings (1994)
Distribution of trinucleotide microsatellites in different categories of mammalian genomic sequence: implications for human genetic diseases.Genomics, 21 1
D. Duboule, M. Haenlin, B. Galliot, E. Mohier (1987)
DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissuesMolecular and Cellular Biology, 7
Mammalian Genome 12, 475–477 (2001). DOI: 10.1007/s003350010290 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Conservation of CAG/CTG trinucleotide repeats in developmentally expressed mammalian genes Thomas W. Dunlop,* R. Wayne Davies University of Glasgow, Institute of Biomedical and Life Sciences, Division of Molecular Genetics, 56 Dumbarton Road, Glasgow G11 6NU, Scotland, UK Received: 27 September 2000 / Accepted: 15 February 2001 Trinucleotide repeats (TNRs) are tandem repetitions of three tively end-labeled (CTG) oligonucleotide probe. The clones nucleotides. In mammalian genomes, the occurrence of different identified represented 0.29% (8.5 d.p.c., B. Hogan), 0.076% (12.5 classes of triplet repeats is non-random. For example, the CAG/ d.p.c., A. Joyner and M. Hanks) and 0.165% (13.5 d.p.c., N. Allen) CTG class of TNR is found frequently in the coding regions of of the total clones screened from each of the cDNA libraries. The mammalian genes (Toth et al. 2000) translated most frequently as total number of positive clones obtained was 96 (from a total of poly-glutamine homopeptides. 60,000 clones screened). A random selection of positive clones Expansion mutations of CAG/CTG, as well as other classes of from the 8.5 d.p.c. (N 4 13) and 12.5 d.p.c. (N 4 6) library trinucleotide repeats,
Mammalian Genome – Springer Journals
Published: Jun 1, 2001
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.