Mammalian Genome 12, 475–477 (2001). DOI: 10.1007/s003350010290 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Conservation of CAG/CTG trinucleotide repeats in developmentally expressed mammalian genes Thomas W. Dunlop,* R. Wayne Davies University of Glasgow, Institute of Biomedical and Life Sciences, Division of Molecular Genetics, 56 Dumbarton Road, Glasgow G11 6NU, Scotland, UK Received: 27 September 2000 / Accepted: 15 February 2001 Trinucleotide repeats (TNRs) are tandem repetitions of three tively end-labeled (CTG) oligonucleotide probe. The clones nucleotides. In mammalian genomes, the occurrence of different identified represented 0.29% (8.5 d.p.c., B. Hogan), 0.076% (12.5 classes of triplet repeats is non-random. For example, the CAG/ d.p.c., A. Joyner and M. Hanks) and 0.165% (13.5 d.p.c., N. Allen) CTG class of TNR is found frequently in the coding regions of of the total clones screened from each of the cDNA libraries. The mammalian genes (Toth et al. 2000) translated most frequently as total number of positive clones obtained was 96 (from a total of poly-glutamine homopeptides. 60,000 clones screened). A random selection of positive clones Expansion mutations of CAG/CTG, as well as other classes of from the 8.5 d.p.c. (N 4 13) and 12.5 d.p.c. (N 4 6) library trinucleotide repeats,
Mammalian Genome – Springer Journals
Published: Jun 1, 2001
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