The conformational changes of 3,5,3′-triiodo L-thyronine induced by interaction with phospholipids were analyzed by Raman spectroscopy. The spectra were interpreted in terms of two conformers of this hormone in equilibrium in the lipid medium, depending on the orientation of the 3′-iodine with respect to the ring α. Theoretical geometry optimizations on both conformers in vacuo and in different solvents, together with the respective calculated energies support the experimental results. The presence of only one iodine atom in the phenolic ring allows assumption of a higher flexibility of 3,5,3′-triiodo L-thyronine and a better accommodation into the lipid medium compared to 3,5,3′,5′-tetraiodo L-thyronine. The possible physiological implications of structural differences that appear in membrane models between 3,5,3′-triiodo L-thyronine and 3,5,3′,5′-tetraiodo L-thyronine are discussed.
The Journal of Membrane Biology – Springer Journals
Published: Jan 1, 2005
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera