Conditional lethal mutations shift the genome from stability to instability

Conditional lethal mutations shift the genome from stability to instability The phenomenology of genomic destabilization is described in Drosophila melanogaster mutants containing radiation-induced conditional dominant lethals in the X chromosome and in autosome 2. Destabilization manifests itself as (1) the loss or decrease of lethality of previously lethal mutations; (2) the loss of expression of visible dominant mutations in an opposite homolog; (3) chromosomal instability resulting in the loss of the X chromosome in germline and somatic cells; (4) the occurrence of novel mutations (secondary mutagenesis); (5) the occurrence of single and mass modifications; (6) disturbances in individual development (formation of morphoses). The key event for the shift of the genome from the stable state into the unstable one is the occurrence of a conditional dominant lethal mutation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Conditional lethal mutations shift the genome from stability to instability

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2009 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S102279540903003X
Publisher site
See Article on Publisher Site

Abstract

The phenomenology of genomic destabilization is described in Drosophila melanogaster mutants containing radiation-induced conditional dominant lethals in the X chromosome and in autosome 2. Destabilization manifests itself as (1) the loss or decrease of lethality of previously lethal mutations; (2) the loss of expression of visible dominant mutations in an opposite homolog; (3) chromosomal instability resulting in the loss of the X chromosome in germline and somatic cells; (4) the occurrence of novel mutations (secondary mutagenesis); (5) the occurrence of single and mass modifications; (6) disturbances in individual development (formation of morphoses). The key event for the shift of the genome from the stable state into the unstable one is the occurrence of a conditional dominant lethal mutation.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Mar 20, 2009

References

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