Concurrent synthesis of vanillin and isovanillin

Concurrent synthesis of vanillin and isovanillin A method for concurrent synthesis of vanillin and isovanillin has been developed by a nonregioselective Vilsmeier–Haack reaction of O-alkyl guaiacols. O-Alkylation of guaiacol provided the corresponding O-alkyl guaiacol (1), which was then formylated with N-methylformanilide/phosphorus oxychloride to give a mixture of 4-alkoxy-3-methoxy-benzaldehyde (2) and 3-alkoxy-4-methoxybenzaldehyde (3). Finally, the obtained mixture underwent a selective dealkylation by anhydrous aluminium trichloride, while leaving methyl groups intact to simultaneously achieve the significant fine chemicals vanillin and isovanillin. Research on Chemical Intermediates Springer Journals

Concurrent synthesis of vanillin and isovanillin

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Springer Netherlands
Copyright © 2012 by Springer Science+Business Media B.V.
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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