Strahlenther Onkol (2018) 194:215–224 https://doi.org/10.1007/s00066-017-1218-6 ORIGINAL ARTICLE Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen Acute toxicity in pediatric high-grade glioma patients 1 2,3,4 2 2 5 Clemens Seidel ·André O.von Bueren ·Sabrina Bojko · Marion Hoffmann · Torsten Pietsch · 5 6 6 1 2 Gerrit H. Gielen · Monika Warmuth-Metz · Brigitte Bison ·Rolf-D. Kortmann ·ChristofM.Kramm Received: 28 March 2017 / Accepted: 19 September 2017 / Published online: 11 October 2017 © Springer-Verlag GmbH Deutschland 2017 Abstract etoposide (PE) and PE plus ifosfamide (PEI) in combina- Purpose As the efﬁcacy of all pediatric high-grade glioma tion with weekly vincristine injections were applied during (HGG) treatments is similar and still disappointing, it is radiochemotherapy in the HIT GBM-C/D protocol. essential to also investigate the toxicity of available treat- Results Regular blood counts and information about cel- ments. lular nadirs were available from 304 patients (leukocytes) Methods Prospectively recorded hematologic and non- and 306 patients (thrombocytes), respectively. Grade 3–4 hematologic toxicities of children treated with radio- leukopenia was much more frequent in the HIT GBM- chemotherapy in the HIT GBM-C/D and HIT-HGG- C/D cohort (n = 88, 52%) vs. HIT-HGG-2007 (n = 13, 2007 trials
Strahlentherapie und Onkologie – Springer Journals
Published: Oct 11, 2017
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