Strahlenther Onkol (2018) 194:215–224 https://doi.org/10.1007/s00066-017-1218-6 ORIGINAL ARTICLE Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen Acute toxicity in pediatric high-grade glioma patients 1 2,3,4 2 2 5 Clemens Seidel ·André O.von Bueren ·Sabrina Bojko · Marion Hoffmann · Torsten Pietsch · 5 6 6 1 2 Gerrit H. Gielen · Monika Warmuth-Metz · Brigitte Bison ·Rolf-D. Kortmann ·ChristofM.Kramm Received: 28 March 2017 / Accepted: 19 September 2017 / Published online: 11 October 2017 © Springer-Verlag GmbH Deutschland 2017 Abstract etoposide (PE) and PE plus ifosfamide (PEI) in combina- Purpose As the efﬁcacy of all pediatric high-grade glioma tion with weekly vincristine injections were applied during (HGG) treatments is similar and still disappointing, it is radiochemotherapy in the HIT GBM-C/D protocol. essential to also investigate the toxicity of available treat- Results Regular blood counts and information about cel- ments. lular nadirs were available from 304 patients (leukocytes) Methods Prospectively recorded hematologic and non- and 306 patients (thrombocytes), respectively. Grade 3–4 hematologic toxicities of children treated with radio- leukopenia was much more frequent in the HIT GBM- chemotherapy in the HIT GBM-C/D and HIT-HGG- C/D cohort (n = 88, 52%) vs. HIT-HGG-2007 (n = 13, 2007 trials
Strahlentherapie und Onkologie – Springer Journals
Published: Oct 11, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud