Int J CARS (2017) 12:1543–1559 DOI 10.1007/s11548-016-1517-x ORIGINAL ARTICLE Comprehensive preclinical evaluation of a multi-physics model of liver tumor radiofrequency ablation 1,2 2 1 2 Chloé Audigier · Tommaso Mansi · Hervé Delingette · Saikiran Rapaka · 2 2 2 3 Tiziano Passerini · Viorel Mihalef · Marie-Pierre Jolly · Raoul Pop · 3 3,4 2 2 Michele Diana · Luc Soler · Ali Kamen · Dorin Comaniciu · Nicholas Ayache Received: 4 August 2016 / Accepted: 21 December 2016 / Published online: 17 January 2017 © CARS 2017 Abstract Keywords Computational modeling · Radiofrequency Purpose We aim at developing a framework for the valida- ablation · Preclinical evaluation tion of a subject-speciﬁc multi-physics model of liver tumor radiofrequency ablation (RFA). Methods The RFA computation becomes subject speciﬁc Introduction after several levels of personalization: geometrical and bio- physical (hemodynamics, heat transfer and an extended During liver tumor radiofrequency ablation (RFA), the clin- cellular necrosis model). We present a comprehensive exper- ician inserts a probe percutaneously or during open surgery imental setup combining multimodal, pre- and postoperative in the liver parenchyma, visualization of the thermal-induced anatomical and functional images, as well as the interven- necrosis progress is then unavailable. Tailoring
International Journal of Computer Assisted Radiology and Surgery – Springer Journals
Published: Jan 17, 2017
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