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Drugs - Real World Outcomes (2018) 5:129–136 https://doi.org/10.1007/s40801-018-0135-z OR IGINAL RESEARCH ARTIC L E Compliance with Pregnancy Prevention Recommendations for Isotretinoin in Estonia in 2012–2016 1 1 2 2 3 • • • • • Anneli Uusku ¨ la Heti Pisarev Katrin Kurvits Ott Laius Made Laanpere Maia Uusku ¨ la Published online: 22 May 2018 The Author(s) 2018 Abstract The odds for full coverage with effective contraception Background Isotretinoin is an effective treatment for sev- increased with the age of the patient, with the duration of ere acne; no alternative treatment has an equal therapeutic isotretinoin treatment and over the period of observation. effect. The teratogenic effects of isotretinoin can be avoi- Conclusion Our study adds to the existing literature doc- ded, and numerous recommendations and regulations are in umenting limited compliance with pregnancy prevention force to minimize the risk of pregnancy during treatment. programs for isotretinoin-containing products, and calls for Objectives To describe isotretinoin prescription patterns program assessment to identify whether new measures for women aged 15–45 years, assess the concomitancy of should be taken or whether weaknesses in policy or isotretinoin and contraceptive use, and determine the rate implementation can be corrected. of potential isotretinoin-exposed pregnancies
Drugs - Real World Outcomes – Springer Journals
Published: May 22, 2018
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