Complete coding sequences of European brown hare syndrome virus (EBHSV) strains isolated in 1982 in Sweden

Complete coding sequences of European brown hare syndrome virus (EBHSV) strains isolated in 1982... European brown hare syndrome (EBHS) is characterised by high mortality of European brown hares ( Lepus europaeus ) and mountain hares ( Lepus timidus ). European brown hare syndrome virus (EBHSV) and the closely related rabbit haemorrhagic disease virus (RHDV) comprise the genus Lagovirus , family Caliciviridae. In contrast to RHDV, which is well studied, with more than 30 complete genome sequences available, the only complete genome sequence available for EBHSV was obtained from a strain isolated in 1989 in France. EBHS was originally diagnosed in Sweden in 1980. Here, we report the complete coding sequences of two EBHSV strains isolated from European brown hares that died with liver lesions characteristic of EBHS in Sweden in 1982. These sequences represent the oldest complete coding sequences of EBHSV isolated from the original area of virus diagnosis. The genomic organisation is similar to that of the published French sequence. Comparison with this sequence revealed several nucleotide substitutions, corresponding to 6 % divergence. At the amino acid level, the Swedish strains are 2 % different from the French strain. Most amino acid substitutions were located within the major capsid protein VP60, but when considering the amino acid sequence length of each protein, VP10 is the protein with the highest percentage of amino acid differences. The same result was obtained when Swedish strains were compared. This evolutionary pattern has not been described previously for members of the genus Lagovirus . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Complete coding sequences of European brown hare syndrome virus (EBHSV) strains isolated in 1982 in Sweden

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Publisher
Springer Vienna
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1714-7
Publisher site
See Article on Publisher Site

Abstract

European brown hare syndrome (EBHS) is characterised by high mortality of European brown hares ( Lepus europaeus ) and mountain hares ( Lepus timidus ). European brown hare syndrome virus (EBHSV) and the closely related rabbit haemorrhagic disease virus (RHDV) comprise the genus Lagovirus , family Caliciviridae. In contrast to RHDV, which is well studied, with more than 30 complete genome sequences available, the only complete genome sequence available for EBHSV was obtained from a strain isolated in 1989 in France. EBHS was originally diagnosed in Sweden in 1980. Here, we report the complete coding sequences of two EBHSV strains isolated from European brown hares that died with liver lesions characteristic of EBHS in Sweden in 1982. These sequences represent the oldest complete coding sequences of EBHSV isolated from the original area of virus diagnosis. The genomic organisation is similar to that of the published French sequence. Comparison with this sequence revealed several nucleotide substitutions, corresponding to 6 % divergence. At the amino acid level, the Swedish strains are 2 % different from the French strain. Most amino acid substitutions were located within the major capsid protein VP60, but when considering the amino acid sequence length of each protein, VP10 is the protein with the highest percentage of amino acid differences. The same result was obtained when Swedish strains were compared. This evolutionary pattern has not been described previously for members of the genus Lagovirus .

Journal

Archives of VirologySpringer Journals

Published: Oct 1, 2013

References

  • Evidence for recombination in the major capsid gene VP60 of the rabbit haemorrhagic disease virus (RHDV)
    Abrantes, J; Esteves, PJ; Loo, W
  • Epidemiology, control and management of an EBHS outbreak in captive hares
    Drews, B; Szentiks, CA; Roellig, K; Fickel, J; Schroeder, K; Duff, JP; Lavazza, A; Hildebrandt, TB; Goeritz, F
  • Molecular epidemiology of European brown hare syndrome virus in France between 1989 and 2003
    Gall-Recule, G; Zwingelstein, F; Laurent, S; Portejoie, Y; Rasschaert, D

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