Diabetologia (2017) 60:1822–1833 DOI 10.1007/s00125-017-4316-1 ARTICLE Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications 1 1 1,2 1 1 1 Ming Zhu & Xiao He & Xiao-Hui Wang & Wei Qiu & Wei Xing & Wei Guo & 1 1 1 1 2 Tian-Chen An & Luo-Quan Ao & Xue-Ting Hu & Zhan Li & Xiao-Ping Liu & 3 4,5 1 1 Nan Xiao & Jian Yu & Hong Huang & Xiang Xu Received: 8 November 2016 /Accepted: 25 April 2017 /Published online: 3 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract a deficiency of circulating MSC-like cells in people with dia- Aims/hypothesis Regeneration and repair mediated by mesen- betes and explored the underlying mechanisms. chymal stem cells (MSCs) are key self-protection mechanisms Methods The abundance of MSC-like cells in peripheral against diabetic complications, a reflection of diabetes-related blood was evaluated by FACS. Selected diabetic and non- cell/tissue damage and dysfunction. MSC abnormalities have diabetic serum (DS and NDS, respectively) samples were used been reported during the progression of diabetic complica- to mimic diabetic and non-diabetic microenvironments, re- tions, but little is known about whether a deficiency in these spectively. The proliferation and survival
Diabetologia – Springer Journals
Published: Jun 3, 2017
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