To study the genome diversity of bacteriophages from geographically distant natural populations, new giant ϕKZ-like Pseudomonas aeruginosa phages isolated in two different regions were compared with earlier known phages of three species (ϕKZ, Lin68, EL). A broad spectrum of lytic activity was demonstrated for all ϕKZ-like phages. Phages of the ϕKZ species proved to be common in natural populations of various regions, while EL- and Lin68-related phages were extremely rare. Most ϕKZ-related phages had unique DNA restriction patterns, but the differences between these were only minor, and the genomes did not contain nonhomologous fragments. The spectrum of capsid polypeptides proved to be conserved in each species, and was proposed as a character necessary and sufficient for express classification of phages with an accuracy of species. Phages isolated in different geographical regions showed no substantial difference. Some phages only slightly differing in DNA restriction pattern from ϕKZ may be used to study the origin of ϕKZ genes coding for orthologs of proteins of unrelated species (other phages, pathogenic bacteria, eukaryotes).
Russian Journal of Genetics – Springer Journals
Published: Oct 18, 2004
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