Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial

Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets... Adv Ther (2017) 34:2022–2032 DOI 10.1007/s12325-017-0585-9 ORIGINAL RESEARCH Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial . . . . Be ´range `re Vasseur Alain Dufour Laetitia Houdas Helen Goodwin . . Kathryn Harries Neslihan Yesiltas Emul Simon Hutchings Received: May 30, 2017 / Published online: July 19, 2017 Springer Healthcare Ltd. 2017 subjects aged 18–50 years. Eligibility was assessed ABSTRACT within 14 days of the first dose. IMP was admin- istered in the fasted state on day 1 of each treat- Introduction: The clonidine mucoadhesive ment period. PK samples were collected up to buccal tablet (MBT) is a novel delivery system 24 h (saliva)/96 h (blood) for measurement of the resulting in high and sustained concentrations clonidine concentration. Safety and tolerability of clonidine in the oral cavity. In a phase II were evaluated at specified times throughout the clinical trial, clonidine MBT reduced the inci- study. A washout period of at least 7 days was dence of severe oral mucositis (OM) compared observed between administrations. to placebo in head and neck cancer patients Results: Clonidine MBT (50 and 100 lg) undergoing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advances in Therapy Springer Journals

Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial

Loading next page...
 
/lp/springer_journal/comparison-of-the-systemic-and-local-pharmacokinetics-of-clonidine-ycrmylSMiF
Publisher
Springer Healthcare
Copyright
Copyright © 2017 by Springer Healthcare Ltd.
Subject
Medicine & Public Health; Internal Medicine; Oncology; Cardiology; Rheumatology; Endocrinology; Pharmacology/Toxicology
ISSN
0741-238X
eISSN
1865-8652
D.O.I.
10.1007/s12325-017-0585-9
Publisher site
See Article on Publisher Site

Abstract

Adv Ther (2017) 34:2022–2032 DOI 10.1007/s12325-017-0585-9 ORIGINAL RESEARCH Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial . . . . Be ´range `re Vasseur Alain Dufour Laetitia Houdas Helen Goodwin . . Kathryn Harries Neslihan Yesiltas Emul Simon Hutchings Received: May 30, 2017 / Published online: July 19, 2017 Springer Healthcare Ltd. 2017 subjects aged 18–50 years. Eligibility was assessed ABSTRACT within 14 days of the first dose. IMP was admin- istered in the fasted state on day 1 of each treat- Introduction: The clonidine mucoadhesive ment period. PK samples were collected up to buccal tablet (MBT) is a novel delivery system 24 h (saliva)/96 h (blood) for measurement of the resulting in high and sustained concentrations clonidine concentration. Safety and tolerability of clonidine in the oral cavity. In a phase II were evaluated at specified times throughout the clinical trial, clonidine MBT reduced the inci- study. A washout period of at least 7 days was dence of severe oral mucositis (OM) compared observed between administrations. to placebo in head and neck cancer patients Results: Clonidine MBT (50 and 100 lg) undergoing

Journal

Advances in TherapySpringer Journals

Published: Jul 19, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off