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A. Lokuta, M. Meyers, P. Sander, G. Fishman, H. Valdivia (1997)
Modulation of Cardiac Ryanodine Receptors by Sorcin*The Journal of Biological Chemistry, 272
R. Sitsapesan, A. Williams (1994)
Gating of the native and purified cardiac SR Ca(2+)-release channel with monovalent cations as permeant species.Biophysical journal, 67 4
Borbala Mazzag, C. Tignanelli, G. Smith (2005)
The effect of residual Ca2+ on the stochastic gating of Ca2+-regulated Ca2+ channel models.Journal of theoretical biology, 235 1
N. Beard, M. Sakowska, A. Dulhunty, D. Laver (2002)
Calsequestrin is an inhibitor of skeletal muscle ryanodine receptor calcium release channels.Biophysical journal, 82 1 Pt 1
(2004)
Luminal Caregulated Mg inhibition of skeletal RYRs reconstituted
M. Endo, T. Kitazawa (1978)
Biophysical Aspects of Cardiac Muscle
Alexandre Fabiato (1992)
Two kinds of calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cardiac cells.Advances in experimental medicine and biology, 311
Li Ching, A. Williams, R. Sitsapesan (2000)
Evidence for Ca(2+) activation and inactivation sites on the luminal side of the cardiac ryanodine receptor complex.Circulation research, 87 3
A. Fabiato, F. Fabiato (1976)
Techniques of skinned cardiac cells and of isolated cardiac fibers with disrupted sarcolemmas with reference to the effects of catecholamines and of caffeine.Recent advances in studies on cardiac structure and metabolism, 9
I. Györke, N. Hester, L. Jones, S. Györke (2004)
The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium.Biophysical journal, 86 4
(2005)
Modification of sarcoplasmic reticulum (SR) Ca release by FK506 induces defective excitation-contraction coupling only when SR Ca recycling
V. Lukyanenko, I. Györke, S. Györke (1996)
Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytesPflugers Arch., 432
A. Tripathy, G. Meissner (1996)
Sarcoplasmic reticulum lumenal Ca2+ has access to cytosolic activation and inactivation sites of skeletal muscle Ca2+ release channel.Biophysical journal, 70 6
Long-Sheng Song, A. Guia, J. Muth, Marta Rubio, Shi-Qiang Wang, R. Xiao, I. Josephson, E. Lakatta, A. Schwartz, Heping Cheng (2002)
Ca2+ Signaling in Cardiac Myocytes Overexpressing the &agr;1 Subunit of L-Type Ca2+ ChannelCirculation Research: Journal of the American Heart Association, 90
R. Sitsapesan, A. Williams (1997)
Regulation of Current Flow through Ryanodine Receptors by Luminal Ca2+The Journal of Membrane Biology, 159
Pin Li, S. Chen (2001)
Molecular Basis of Ca2+ Activation of the Mouse Cardiac Ca2+ Release Channel (Ryanodine Receptor)The Journal of General Physiology, 118
Long-Sheng Song, A. Guia, J. Muth, Marta Rubio, Shi-Qiang Wang, R. Xiao, I. Josephson, E. Lakatta, A. Schwartz, Heping Cheng (2002)
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.Circulation research, 90 2
Wei Liu, D. Pasek, G. Meissner (1997)
Modulation of Ca 2 1-gated cardiac muscle Ca 2 1-release channel ( ryanodine receptor ) by mono-and divalent ions
N. Beard, D. Laver, A. Dulhunty (2004)
Calsequestrin and the calcium release channel of skeletal and cardiac muscle.Progress in biophysics and molecular biology, 85 1
Le Xu, G. Meissner (1998)
Regulation of cardiac muscle Ca2+ release channel by sarcoplasmic reticulum lumenal Ca2+.Biophysical journal, 75 5
Rebecca Sitsapesan, A. Williams (1990)
Mechanisms of caffeine activation of single calcium‐release channels of sheep cardiac sarcoplasmic reticulum.The Journal of Physiology, 423
I. Györke, S. Gyorke (1998)
Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites.Biophysical journal, 75 6
D. Laver, E. O’Neill, G. Lamb (2004)
Luminal Ca2+–regulated Mg2+ Inhibition of Skeletal RyRs Reconstituted as Isolated Channels or Coupled ClustersThe Journal of General Physiology, 124
R. Sitsapesan, A. Williams (1994)
Regulation of the gating of the sheep cardiac sarcoplasmic reticulum ca2+-release channel by luminal Ca2+The Journal of Membrane Biology, 137
(1994)
Ca-release channel by luminal Ca
M. Endo, T. Kitazawa (1978)
E-C COUPLING STUDIES ON SKINNED CARDIAC FIBERS
A. Fabiato (1985)
Time and calcium dependence of activation and inactivation of calcium- induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cellThe Journal of General Physiology, 85
G. Meissner (1994)
Ryanodine receptor/Ca2+ release channels and their regulation by endogenous effectors.Annual review of physiology, 56
E. Buck, W. Lachnit, I. Pessah (1999)
Mechanisms of delta-hexachlorocyclohexane toxicity: I. Relationship between altered ventricular myocyte contractility and ryanodine receptor function.The Journal of pharmacology and experimental therapeutics, 289 1
(2005)
The effect of residual Ca 2 + on the stochastic gating of Ca 2 + - regulated Ca 2 + channel models
(2002)
Ca signaling in cardiac myocytes overexpressing the a1 subunit of L-type Ca
A. Fabiato, F. Fabiato (1979)
Use of chlorotetracycline fluorescence to demonstrate Ca2+-induced release of Ca2+ from the sarcoplasmic reticulum of skinned cardiac cellsNature, 281
E. Buck, I. Pessah (1999)
Mechanisms of d-Hexachlorocyclohexane Toxicity : II . Evidence for Ca 2 1-Dependent K 1-Selective Ionophore Activity 1
N. Dhalla, McNamara Db, Anand Mb (1976)
Heart sarcolemma as a dynamic excitable membrane.Recent advances in studies on cardiac structure and metabolism, 9
Wei Liu, D. Pasek, G. Meissner (1998)
Modulation of Ca2+-gated cardiac muscle Ca2+-release channel (ryanodine receptor) by mono- and divalent ions.American journal of physiology. Cell physiology, 274 1
S. Yoshihara, H. Satoh, M. Saotome, H. Katoh, H. Terada, Hiroshi Watanabe, H. Hayashi (2005)
Modification of sarcoplasmic reticulum (SR) Ca2+ release by FK506 induces defective excitation-contraction coupling only when SR Ca2+ recycling is disturbed.Canadian journal of physiology and pharmacology, 83 4
Ca2+ released from the sarcoplasmic reticulum (SR) via ryanodine receptor type 2 (RYR2) is the key determinant of cardiac contractility. Although activity of RYR2 channels is primary controlled by Ca2+ entry through the plasma membrane, there is growing evidence that Ca2+ in the lumen of the SR can also be effectively involved in the regulation of RYR2 channel function. In the present study, we investigated the effect of luminal Ca2+ on the response of RYR2 channels reconstituted into a planar lipid membrane to caffeine and Ca2+ added to the cytosolic side of the channel. We performed two sets of experiments when the channel was exposed to either luminal Ba2+ or Ca2+. The given ion served also as a charge carrier. Luminal Ca2+ effectively shifted the EC50 for caffeine sensitivity to a lower concentration but did not modify the response of RYR2 channels to cytosolic Ca2+. Importantly, luminal Ca2+ exerted an effect on channel gating kinetics. Both the open and closed dwell times were considerably prolonged over the whole range (response to caffeine) or the partial range (response to cytosolic Ca2+) of open probability. Our results provide strong evidence that an alteration of the gating kinetics is the result of the interaction of luminal Ca2+ with the luminally located Ca2+ regulatory sites on the RYR2 channel complex.
The Journal of Membrane Biology – Springer Journals
Published: Jan 6, 2007
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