Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy

Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy The prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2% of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be more efficacious than SLIT with an acceptable safety profile. However, SLIT is associated with fewer side effects. Studies indicate that a combination of SLIT and OIT may together induce a significant increase in challenge thresholds with fewer adverse events. More head-to-head clinical trials that directly compare OIT and SLIT as well as SLIT and OIT combination studies are warranted. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Allergo Journal International Springer Journals

Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Medizin Verlag GmbH, a part of Springer Nature
Subject
Medicine & Public Health; Allergology; Dermatology; Environmental Health; Immunology
eISSN
2197-0378
D.O.I.
10.1007/s40629-018-0067-x
Publisher site
See Article on Publisher Site

Abstract

The prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2% of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be more efficacious than SLIT with an acceptable safety profile. However, SLIT is associated with fewer side effects. Studies indicate that a combination of SLIT and OIT may together induce a significant increase in challenge thresholds with fewer adverse events. More head-to-head clinical trials that directly compare OIT and SLIT as well as SLIT and OIT combination studies are warranted.

Journal

Allergo Journal InternationalSpringer Journals

Published: Jun 6, 2018

References

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