Purpose To evaluate oxygen consumption by photoreceptors, we estimated changes in pre-retinal oxygen pressure (PO )after selective retina therapy (SRT) compared with conventional photocoagulation (PC) in rabbits. Methods One eye of each of 10 Chinchilla Bastard rabbits received both 144 laser SRT spots and 144 laser PC spots. Color fundus photography, optical coherence tomography (OCT), and fluorescein angiography were used to evaluate the lesions after treatment. Fiber-optic sensors (optodes) were used to determine the pre-retinal PO levels of untreated, SRT-treated, and PC- treated areas of laser-damaged eyes 7 days after treatment. The pre-retinal PO was measured in the other five eyes (controls). The same procedures were applied to these remaining five eyes 4 weeks after treatment. Light microscopy (LM) was used to evaluate histological changes 7 days and 4 weeks after treatment. Results We found no significant difference in the mean pre-retinal PO values among untreated, SRT-treated, and control eyes 7 days after treatment. However, the mean pre-retinal PO value in PC-treated regions (24.3 ± 4.9 mmHg; mean ± SD) was higher than those in untreated regions (17.0 ± 1.8 mmHg; P = 0.019), SRT-treated regions (16.7 ± 2.6 mmHg; P = 0.015), and controls (16.9 ± 2.4 mmHg;
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: Jun 2, 2018
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