Comparison of Clozapine Response for Inpatients
in the Research Setting Versus Routine Clinical Practice
Douglas L. Boggs Æ Deanna L. Kelly Æ Raymond C. Love Æ Robert P. McMahon Æ
Robert R. Conley
Published online: 24 January 2008
Ó Springer Science+Business Media, LLC 2008
This study compares patient characteristics and treatment response between
inpatients treated with clozapine in a research setting as compared to those initiated on
clozapine during routine inpatient treatment.
Subjects on clozapine, in clinical trials, were compared with clozapine inpa-
tients receiving routine clinical care.
At baseline, patients in routine clinical practice had more negative symptoms
(P \ 0.001), activation (P \ 0.001) and greater total Brief Psychiatric Rating Scale
(BPRS) scores (P = 0.022) than those in the research setting. Routine clinical practice
subjects had larger decreases in BPRS total scores (P = 0.042) and positive item scores
(P = 0.0005) compared to research subjects. Response to clozapine was observed in 15/85
(18%) research subjects as compared to 60/223 (27%) patients in routine care (P = 0.09).
Patients treated in routine clinical practice have more severe baseline
symptoms, but experience signiﬁcantly greater improvements in psychiatric symptoms.
D. L. Boggs Á D. L. Kelly (&) Á R. P. McMahon Á R. R. Conley
Maryland Psychiatric Research Center, University of Maryland Baltimore,
School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
D. L. Boggs
R. P. McMahon
R. R. Conley
R. C. Love
University of Maryland Baltimore, School of Pharmacy, 20 N.Pine Street,
Room 440, Baltimore, MD 21201, USA
Psychiatr Q (2008) 79:111–119