Comparison of calcium phosphate preparations for onlay cranial augmentation in a murine model

Comparison of calcium phosphate preparations for onlay cranial augmentation in a murine model Calcium phosphate preparations are often employed for a variety of reconstructive tasks. The majority of existing data regarding these preparations relates to their use as an inlay implant. The present study aims to evaluate calcium phosphate preparations and their tissue characteristics related to onlay augmentation. Thirty-six research mice were divided into three groups of 12. Each animal underwent onlay augmentation with a calcium phosphate preparation. Group 1 members were subjected to hydroxyapatite (HA) paste while group 2 was treated with beta-tricalcium phosphate granules alone (TCP). Finally, group 3 was treated with a combined mixture of both substances (HA-TCP). The animals were harvested for histological analysis and data collection. Groups 2 (TCP) and 3 (HA-TCP) developed greater osteoneogenesis and tissue integration compared to Group 1 (HA). The results were found to be statistically significant ( p < 0.01). Calcium phosphate preparations including TCP alone or in combination with HA undergo greater osteoneogenesis and soft tissue integration compared with hydroxapatite alone when used as an onlay implant in the animal model. Therapeutic study — Level II. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Comparison of calcium phosphate preparations for onlay cranial augmentation in a murine model

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Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer-Verlag
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-012-0702-6
Publisher site
See Article on Publisher Site

Abstract

Calcium phosphate preparations are often employed for a variety of reconstructive tasks. The majority of existing data regarding these preparations relates to their use as an inlay implant. The present study aims to evaluate calcium phosphate preparations and their tissue characteristics related to onlay augmentation. Thirty-six research mice were divided into three groups of 12. Each animal underwent onlay augmentation with a calcium phosphate preparation. Group 1 members were subjected to hydroxyapatite (HA) paste while group 2 was treated with beta-tricalcium phosphate granules alone (TCP). Finally, group 3 was treated with a combined mixture of both substances (HA-TCP). The animals were harvested for histological analysis and data collection. Groups 2 (TCP) and 3 (HA-TCP) developed greater osteoneogenesis and tissue integration compared to Group 1 (HA). The results were found to be statistically significant ( p < 0.01). Calcium phosphate preparations including TCP alone or in combination with HA undergo greater osteoneogenesis and soft tissue integration compared with hydroxapatite alone when used as an onlay implant in the animal model. Therapeutic study — Level II.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Jul 1, 2012

References

  • Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis
    Pezzatini, S; Morbidelli, L; Solito, R; Paccagnini, E; Boanini, E; Bigi, A
  • Use of hydroxyapatite in spine surgery
    Spivak, JM; Hasharoni, A

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