Comparison Between Cyano and C-18 Columns for Separation of Trandolapril and Verapamil with ESI-Q-ToF-MS Characterization of Acidic and Basic Degradation Products: Stability Indicating Assay Methods

Comparison Between Cyano and C-18 Columns for Separation of Trandolapril and Verapamil with... Extended author information available on the last page of the article Vol.:(0123456789) 1 3 A. Hemdan et al. Keywords Stability indicating assay · C-18 column · Cyano column · Trandolapril · Verapamil Introduction Experimental Trandolapril is an angiotensin converting enzyme (ACE) Materials inhibitor that is used as an antihypertensive drug for patients with left ventricular systolic dysfunction [1, 2]. Trandolapril and Verapamil hydrochloride reference stand- After deesterification, it is converted to Trandolaprilat ards were kindly supplied by Abbott laboratories for phar- (TRPT), which is the active metabolite of Trandolapril [3]. maceuticals and chemical industries (USA). Trandolapril Trandolapril has been approved by the FDA in 1996 and Related Compound E (Trandolaprilat) was obtained from is available as a single drug or in combination with Vera- Sigma Aldrich (Germany). The structures of the studied pamil (Tarka, Abbott Laboratories) which is an immedi- drugs are presented in Fig. 1. Tarka tablets containing 2 mg ate release formulation of Trandolapril and a slow release TRP and 180 mg VRP hydrochloride were obtained from the formulation of Verapamil [4]. local market. Acetonitrile, HPLC-grade was obtained from Verapamil is a calcium channel blocker which affects the (Sigma-Aldrich, Germany). influx of calcium across the cell membrane of the arterial smooth muscle and in contractile myocardial http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chromatographia Springer Journals

Comparison Between Cyano and C-18 Columns for Separation of Trandolapril and Verapamil with ESI-Q-ToF-MS Characterization of Acidic and Basic Degradation Products: Stability Indicating Assay Methods

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Chemistry; Chromatography; Proteomics; Pharmacy; Laboratory Medicine; Analytical Chemistry
ISSN
0009-5893
eISSN
1612-1112
D.O.I.
10.1007/s10337-018-3547-8
Publisher site
See Article on Publisher Site

Abstract

Extended author information available on the last page of the article Vol.:(0123456789) 1 3 A. Hemdan et al. Keywords Stability indicating assay · C-18 column · Cyano column · Trandolapril · Verapamil Introduction Experimental Trandolapril is an angiotensin converting enzyme (ACE) Materials inhibitor that is used as an antihypertensive drug for patients with left ventricular systolic dysfunction [1, 2]. Trandolapril and Verapamil hydrochloride reference stand- After deesterification, it is converted to Trandolaprilat ards were kindly supplied by Abbott laboratories for phar- (TRPT), which is the active metabolite of Trandolapril [3]. maceuticals and chemical industries (USA). Trandolapril Trandolapril has been approved by the FDA in 1996 and Related Compound E (Trandolaprilat) was obtained from is available as a single drug or in combination with Vera- Sigma Aldrich (Germany). The structures of the studied pamil (Tarka, Abbott Laboratories) which is an immedi- drugs are presented in Fig. 1. Tarka tablets containing 2 mg ate release formulation of Trandolapril and a slow release TRP and 180 mg VRP hydrochloride were obtained from the formulation of Verapamil [4]. local market. Acetonitrile, HPLC-grade was obtained from Verapamil is a calcium channel blocker which affects the (Sigma-Aldrich, Germany). influx of calcium across the cell membrane of the arterial smooth muscle and in contractile myocardial

Journal

ChromatographiaSpringer Journals

Published: Jun 5, 2018

References

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