Extended author information available on the last page of the article Vol.:(0123456789) 1 3 1164 A. Hemdan et al. Keywords Stability indicating assay · C-18 column · Cyano column · Trandolapril · Verapamil Introduction Experimental Trandolapril is an angiotensin converting enzyme (ACE) Materials inhibitor that is used as an antihypertensive drug for patients with left ventricular systolic dysfunction [1, 2]. Trandolapril and Verapamil hydrochloride reference stand- After deesterification, it is converted to Trandolaprilat ards were kindly supplied by Abbott laboratories for phar- (TRPT), which is the active metabolite of Trandolapril . maceuticals and chemical industries (USA). Trandolapril Trandolapril has been approved by the FDA in 1996 and Related Compound E (Trandolaprilat) was obtained from is available as a single drug or in combination with Vera- Sigma Aldrich (Germany). The structures of the studied pamil (Tarka, Abbott Laboratories) which is an immedi- drugs are presented in Fig. 1. Tarka tablets containing 2 mg ate release formulation of Trandolapril and a slow release TRP and 180 mg VRP hydrochloride were obtained from the formulation of Verapamil . local market. Acetonitrile, HPLC-grade was obtained from Verapamil is a calcium channel blocker which affects the (Sigma-Aldrich, Germany). influx of calcium across the cell membrane of the arterial smooth muscle and in contractile
Chromatographia – Springer Journals
Published: Jun 5, 2018
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