Purpose Tumor growth is closely related to the development of an intrinsic vascular network. However, microvascular appearance was not regarding highly to pathological diagnosis, though clinical applicability of endoscopic narrow-bad imag- ing (NBI) is developed in the oral cavity. To analyze changes of intraepithelial papillary capillary loop (IPCLs) patterns as the utility for pathological diagnosis, comparative histomorphometric analysis of IPCLs among squamous cell hyperplasia, leukoplakia with low- or high-grade dysplasia, and oral squamous cell carcinoma (OSCC) had performed. Methods Subjects were 40 clinically hyperkeratosis, histologically consisted 5 groups; each 10 of squamous cell hyperplasia, low- or high-grade dysplasia, OSCC and normal mucosae. Sections with smooth muscle actin and CD34 immunoreactivi- ties were used to examine comparative histomorphometric analysis on the basis of IPCL irregularities. The area, shortest diameter, proximity to the basement membrane and circularity were measured using Win Roof image analysis software. Statistical analyses were done by Kruskal–Wallis and Steel–Dwass tests. Values of p < 0.05 were considered significant. Results Larger vessel diameter/areas, more extension and smaller circularity with dysplastic grading, and OSCC showed the most prominent of them. In short, the changes in vessels of IPCLs in high-grade dysplasia and OSCC involve two factors: increased vessel diameter
Oral Cancer – Springer Journals
Published: Mar 12, 2018
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