Originalien Z Rheumatol 2017 · 76:904–912 Y. H. Lee · G. G. Song DOI 10.1007/s00393-016-0186-z Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea Published online: 8 September 2016 University College of Medicine, Seoul, Korea © Springer-Verlag Berlin Heidelberg 2016 Redaktion U. Müller-Ladner, Bad Nauheim Comparative eﬃcacy and safety U. Lange, Bad Nauheim of tacrolimus, mycophenolate mofetil, azathioprine, and cyclophosphamide as maintenance therapy for lupus nephritis A Bayesian network meta-analysis of randomized controlled trials and ovarian toxicity . Other immuno- as maintenance therapy for this indica- Introduction suppressive drugs used for maintenance tion . Evidence from a small number Renal involvement occurs in up to 60 % treatment of lupus nephritis include my- of RCTs comparing the relative eﬃcacy of patients with systemic lupus erythe- cophenolate mofetil (MMF), tacrolimus, and safety of tacrolimus, MMF, AZA, matosus (SLE) and remains a predomi- and azathioprine (AZA). and CYC as maintenance treatment for nant cause of morbidity and mortality in Several meta-analysis studies have lupus nephritis has been inconclusive, SLE  The treatment of lupus nephritis attempted to evaluate the eﬃcacy and mainly because of small sample sizes. consists of an induction phase to produce safety of tacrolimus, MMF,
Zeitschrift für Rheumatologie – Springer Journals
Published: Sep 8, 2016
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