Comparative analysis of LTR and structural genes in an equine infectious anemia virus strain isolated from a feral horse in Japan

Comparative analysis of LTR and structural genes in an equine infectious anemia virus strain... Although equine infectious anemia virus (EIAV) poses a major threat to the equine industry worldwide, the molecular epidemiology of this virus is poorly understood. Recently, an EIAV strain (EIAV Miyazaki2011-A ) representing a new monophyletic group was discovered in feral horses in southern Japan. In the present study, the EIAV Miyazaki2011-A proviral genome is compared with evolutionarily divergent EIAV isolates to investigate conservation of functional elements or motifs within the long terminal repeats (LTRs) and structural genes. This analysis represents a significant step forward in increasing understanding of the molecular conservation and variation between geographically distinct strains of this equine lentivirus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Comparative analysis of LTR and structural genes in an equine infectious anemia virus strain isolated from a feral horse in Japan

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-014-2206-0
Publisher site
See Article on Publisher Site

Abstract

Although equine infectious anemia virus (EIAV) poses a major threat to the equine industry worldwide, the molecular epidemiology of this virus is poorly understood. Recently, an EIAV strain (EIAV Miyazaki2011-A ) representing a new monophyletic group was discovered in feral horses in southern Japan. In the present study, the EIAV Miyazaki2011-A proviral genome is compared with evolutionarily divergent EIAV isolates to investigate conservation of functional elements or motifs within the long terminal repeats (LTRs) and structural genes. This analysis represents a significant step forward in increasing understanding of the molecular conservation and variation between geographically distinct strains of this equine lentivirus.

Journal

Archives of VirologySpringer Journals

Published: Dec 1, 2014

References

  • Detection, molecular characterization and phylogenetic analysis of full-length equine infectious anemia (EIAV) gag genes isolated from Shackleford Banks wild horses
    Capomaccio, S; Willand, ZA; Cook, SJ; Issel, CJ; Santos, EM; Reis, JK; Cook, RF
  • Identification of cellular proteins interacting with equine infectious anemia virus S2 protein
    Covaleda, L; Gno, BT; Fuller, FJ; Payne, SL
  • Crystal structure of dUTPase from equine infectious anaemia virus; active site metal binding in a substrate analogue complex
    Dauter, Z; Persson, R; Rosengren, AM; Nyman, PO; Wilson, KS; Cedergren-Zeppezauer, ES
  • Development of a nested PCR assay to detect equine infectious anemia proviral DNA from peripheral blood of naturally infected horses
    Dong, JB; Zhu, W; Cook, FR; Goto, Y; Horii, Y; Haga, T
  • The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc
    Eijkelenboom, AP; Ent, FM; Vos, A; Doreleijers, JF; Hard, K; Tullius, TD; Plasterk, RH; Kaptein, R; Boelens, R
  • Long terminal repeats are not the sole determinants of virulence for equine infectious anemia virus
    Tu, YB; Zhou, T; Yuan, XF; Qiu, HJ; Xue, F; Sun, CQ; Wang, L; Wu, DL; Peng, JM; Kong, XG; Tong, GZ

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