Mammalian Genome 12, 478–483 (2001). DOI: 10.1007/s003350030004 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Denise Clarke, Greg Elgar, Melody S. Clark HGMP Resource Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SB, UK Received: 6 November 2000 / Accepted: 1 February 2001 With the draft human sequence available, there is increasing in- from mouse BAC396E12 (kindly provided by Lisa Stubbs, Joint terest in the role of comparative genomics as an interpretive tool. Genome Institute, in advance of data submission), which maps to The utility of comparative genomics is to aid, not only in the mouse Chromosome 8, and includes mapping data from Mouse deciphering of gene function, but also the understanding of the Genome Database. importance of conserved gene order. It is currently not known The Fugu data were compared with those of human and mouse, whether gene positioning along a chromosome is random or under the only other organisms for which comprehensive map data are functional constraints. Mapping and localized in-depth sequencing available (Fig. 1). The human 19p12-13 region contains seven of vertebrates evolutionarily distant from human will enable this genes, all of which are present in the same gene order in the question to be addressed
Mammalian Genome – Springer Journals
Published: Jun 1, 2001
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