Arch Toxicol (2017) 91:3189–3190 DOI 10.1007/s00204-017-1992-z LETTER TO THE EDITOR, NEWS AND VIEWS Commentary to Merwin SJ, Obis T, Nunez Y, Re DB (2017) Organophosphate neurotoxicity to the voluntary motor system on the trail of environment‑caused amyotrophic lateral sclerosis: the known, the misknown, and the unknown. Arch Toxicol [Epub ahead of print]. doi:10.1007/s00204‑016‑1926‑1 1 2 Marcello Lotti · Angelo Moretto Received: 8 May 2017 / Accepted: 16 May 2017 / Published online: 24 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Merwin et al. (2017) discuss in the archives about the disease. On the contrary, striking differences in all clinical hypothesis that a better understanding of amyotrophic aspects of these disorders deserve attention, particularly lateral sclerosis (ALS) may benefit from that of when the intention is that to suggest common/similar delayed polyneuropathy occurring after high doses of mechanisms and models. The El Escorial criteria of the organophosphorus esters (OPIDP). The starting points World Federation of Neurology (Acosta et al. 2015), for the hypothesis include some epidemiological studies reviews (Mitchell and Borasio 2007; Kiernan et al. 2011) linking ALS with organophosphates (OPs) exposures, the and textbooks (Aminoff et al. 2005) indicating the criteria clinical features of ALS that are thought to
Archives of Toxicology – Springer Journals
Published: May 24, 2017
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