Commentary on “Late complications after application of polyacrylamide hydrogel” by Evstatiev

Commentary on “Late complications after application of polyacrylamide hydrogel” by Evstatiev Eur J Plast Surg (2006) 29: 139 DOI 10.1007/s00238-006-0059-9 INVITED COMMENTARY R. Schmidt Commentary on “Late complications after application of polyacrylamide hydrogel” by Evstatiev Published online: 30 May 2006 # Springer-Verlag 2006 Abstract The filling material described should be prop- and lasting augmentation; otherwise, some details about erly identified and/or correctly cited. pH is missing a value. using the 5% hydrogel directly would be appreciated. The hydrogel is claimed to contain tetramethylenediamine, which from a chemistry point of view is questionable; it probably should be N, N, N′, N′-tetramethylethylenedia- Discussion mine, which may be used as initiator in polyacrylamide systems. The author claims (pp. 8–9) that complications are not limited to certain producers because the ingredients of the material (polyacrylamide hydrogels?) are always the same, Introduction no matter who produces it. This is an oversimplified statement indicating lack of any knowledge of polymer In this study, the hydrogel is claimed to be from Interfall, chemistry and processing insight. Cross-linked polyacryl- Ukraine. This hydrogel is stated to be 5% (dry solids), amide may be processed based on the same ingredients, but which may be difficult to inject directly; therefore, a different processing conditions will influence the final common practice by physicians is to further dilute the product’s performance drastically. By complying with the hydrogel by introducing sterile isotonic water (sometimes regulatory requirements as for instance to get a CE mark, with a water-soluble analgetic) and mix it in the vial or such a producer is expected to demonstrate documented syringe before injecting. Any such practice is not men- and well-controlled processing facilities and batch records, tioned, but if used, it may influence the success for correct and in particular ensure product sterility, repeatably. Furthermore, some producers have developed rational technologies that provide more consistent hydrogels than others in terms of smaller batch-to-batch variation in hydrogel characteristics, such as pH, dry solids, and rhe- ological performance. There are technologies that provide This commentary refers to the article http://dx.doi.org/10.1007/ s00238-006-0055-0. consistent cross-linking of polyacrylamide hydrogels. This means that despite having the same ingredients, some R. Schmidt (*) producers appreciate the value of obtaining a high level of Chempilots a/s, production control and to supply hydrogels with consistent Farum, Denmark e-mail: rs@chempilots.dk structure and properties. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Commentary on “Late complications after application of polyacrylamide hydrogel” by Evstatiev

Free
1 page
Loading next page...
1 Page
 
/lp/springer_journal/commentary-on-late-complications-after-application-of-polyacrylamide-q7cxYs6ZLy
Publisher
Springer-Verlag
Copyright
Copyright © 2006 by Springer-Verlag
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-006-0059-9
Publisher site
See Article on Publisher Site

Abstract

Eur J Plast Surg (2006) 29: 139 DOI 10.1007/s00238-006-0059-9 INVITED COMMENTARY R. Schmidt Commentary on “Late complications after application of polyacrylamide hydrogel” by Evstatiev Published online: 30 May 2006 # Springer-Verlag 2006 Abstract The filling material described should be prop- and lasting augmentation; otherwise, some details about erly identified and/or correctly cited. pH is missing a value. using the 5% hydrogel directly would be appreciated. The hydrogel is claimed to contain tetramethylenediamine, which from a chemistry point of view is questionable; it probably should be N, N, N′, N′-tetramethylethylenedia- Discussion mine, which may be used as initiator in polyacrylamide systems. The author claims (pp. 8–9) that complications are not limited to certain producers because the ingredients of the material (polyacrylamide hydrogels?) are always the same, Introduction no matter who produces it. This is an oversimplified statement indicating lack of any knowledge of polymer In this study, the hydrogel is claimed to be from Interfall, chemistry and processing insight. Cross-linked polyacryl- Ukraine. This hydrogel is stated to be 5% (dry solids), amide may be processed based on the same ingredients, but which may be difficult to inject directly; therefore, a different processing conditions will influence the final common practice by physicians is to further dilute the product’s performance drastically. By complying with the hydrogel by introducing sterile isotonic water (sometimes regulatory requirements as for instance to get a CE mark, with a water-soluble analgetic) and mix it in the vial or such a producer is expected to demonstrate documented syringe before injecting. Any such practice is not men- and well-controlled processing facilities and batch records, tioned, but if used, it may influence the success for correct and in particular ensure product sterility, repeatably. Furthermore, some producers have developed rational technologies that provide more consistent hydrogels than others in terms of smaller batch-to-batch variation in hydrogel characteristics, such as pH, dry solids, and rhe- ological performance. There are technologies that provide This commentary refers to the article http://dx.doi.org/10.1007/ s00238-006-0055-0. consistent cross-linking of polyacrylamide hydrogels. This means that despite having the same ingredients, some R. Schmidt (*) producers appreciate the value of obtaining a high level of Chempilots a/s, production control and to supply hydrogels with consistent Farum, Denmark e-mail: rs@chempilots.dk structure and properties.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Sep 1, 2006

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from Google Scholar, PubMed
Create lists to organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off