Comment on “The effect of capsaicin ointment on skin for the survival of a cutaneous flap” by T. Miyawaki et al.

Comment on “The effect of capsaicin ointment on skin for the survival of a cutaneous flap” by... Eur J Plast Surg (2001) 24:31 DOI 10.1007/s002380000222 INVITED COMMENTAR Y M. Voigt Comment on “The effect of capsaicin ointment on skin for the survival of a cutaneous flap” by T. Miyawaki et al. Published online: 19 January 2001 © Springer-Verlag 2001 The authors present their interesting work about en- (group D). The authors explain this contradiction by sug- hancement of survival in failing skin flaps by a capsa- gesting that capsaicin ointment interfered with the icin-containing ointment. The study is straightforward wound healing process in the groups in which the oint- and well done. A rat model was chosen in which ment was applied topically. However, no wound infec- 2×10 cm abdominal skin flaps were raised which devel- tion or delayed wound healing was mentioned. oped necrosis at the distal randomized perfused edge. In A blood steal phenomenon and/or stasis of the flap’s this model the effect of capsaicin ointment on skin flap microcirculation due to vasodilation might account for survival was evaluated in four groups, applying the oint- the decreased survival in group D. In addition, the long ment base without capsaicin (group A), capsaicin onto term depletion of neuropeptides could play a role in con- the flap (group B), capsaicin onto the skin around the trolling the A-V shunts in and around the flap. Some flap (group C), and capsaicin ointment around the flap studies suggest these mechanisms [1,2]. Before capsaicin and on the flap's skin (group D). ointment can be used to enhance skin flap survival, one Interestingly, best flap survival was achieved in group should know where the substance should be placed to C, in which capsaicin ointment was applied on the nor- achieve the best effect. It might be interesting to design a mal abdominal skin sparing the flap itself. One would study comparing capsaicin and nitroglycerin effects on have expected the best survival to be seen in flaps which flap survival, because the mechanism of action of nitro- were surrounded and topically treated by the ointment glycerin is less complex than that of capsaicin. This commentary refers to the article: http://dx.doi.org/10.1007/ References s002380000221 M. Voigt ( ) 1. Chang CC, Maruyama Y, Inomata K (1990) Increased flap sur- Universität Freiburg, Chirurgische Klinik, vival after sensory denervation with capsaicin accompanied by Abteilung Plastische und Handchirurgie, delay. J Reconstr Microsurg 6:29–33 Hugstetter Strasse 55, 79106 Freiburg, Germany 2. Westin M, Heden P (1989) Sensory denervation with capsaicin e-mail: voigt@ch11.ukl.uni-freiburg.de does not influence the critical ischemia time in rat island flaps. Tel.: +49-761-2702817, Fax: +49-761-2702501 Scand J Plast Reconstr Surg Hand Surg 23:173–176 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Comment on “The effect of capsaicin ointment on skin for the survival of a cutaneous flap” by T. Miyawaki et al.

Free
1 page

Loading next page...
1 Page
 
/lp/springer_journal/comment-on-the-effect-of-capsaicin-ointment-on-skin-for-the-survival-nuRcoTA0EY
Publisher
Springer-Verlag
Copyright
Copyright © 2000 by Springer-Verlag
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s002380000222
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial