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/lp/springer_journal/colorectal-polyps-in-childhood-cancer-survivors-treated-with-radiation-pyXEh0dl8Z
- Publisher
- Springer Journals
- Copyright
- Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
- Subject
- Medicine & Public Health; Gastroenterology; Hepatology; Oncology; Transplant Surgery; Biochemistry, general
- ISSN
- 0163-2116
- eISSN
- 1573-2568
- DOI
- 10.1007/s10620-018-5138-9
- pmid
- 29855768
- Publisher site
- See Article on Publisher Site
Abstract
Background Cancer survivors treated with abdominal or pelvic radiation therapy (RT) for childhood cancer have an increased risk of colorectal cancer. However, clinical guidelines are inconsistent on recommendations regarding the early initiation of screening in these patients due to the lack of supporting evidence that these patients pass through a pre-invasive phase, in which adenomatous polyps can be detected and removed. Aims To determine the prevalence of adenomatous polyps in cancer survivors treated with RT for childhood cancer; the prevalence in average-risk patients aged 17–49; and the prevalence in average-risk patients aged 50–75. Methods We conducted a retrospective study comparing the prevalence of adenomatous polyps among three patient groups: childhood cancer survivors aged 17–49 with prior RT who underwent colonoscopy screening from 2006 to 2017; age- and gender-matched patients in the average-risk population; and average-risk patients aged 50–75. Results One hundred and forty-five patients were included in the study. The proportion of patients with adenomatous polyps in the cancer survivor group was significantly higher than that in the age- and gender-matched average-risk group (58.6 vs 17.2%, p = 0.00) and higher than the average-risk group aged 50–75 (58.6 vs 27.6%, p = 0.009). The prevalence of adenomas with high-risk
Journal
Digestive Diseases and Sciences – Springer Journals
Published: May 31, 2018