Coinfection with multiple strains of bovine papular stomatitis virus

Coinfection with multiple strains of bovine papular stomatitis virus Bovine papular stomatitis virus (BPSV) infects cattle and, occupationally, humans. Prevalent subclinical infections, frequent reinfections, and virus persistence in healthy animals compound a poorly understood, but likely complex, scenario of BPSV perpetuation and transmission in nature. Here, we report the isolation of multiple BPSV strains coinfecting a single animal. Whole-genome analysis of isolated BPSV strains revealed genomic variability likely affecting virus virulence and infectivity. Further, incongruent phylogenetic relationships between viruses suggested genomic recombination. These results have significant implications for parapoxvirus infection biology and virus evolution in nature. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Coinfection with multiple strains of bovine papular stomatitis virus

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Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2394-2
Publisher site
See Article on Publisher Site

Abstract

Bovine papular stomatitis virus (BPSV) infects cattle and, occupationally, humans. Prevalent subclinical infections, frequent reinfections, and virus persistence in healthy animals compound a poorly understood, but likely complex, scenario of BPSV perpetuation and transmission in nature. Here, we report the isolation of multiple BPSV strains coinfecting a single animal. Whole-genome analysis of isolated BPSV strains revealed genomic variability likely affecting virus virulence and infectivity. Further, incongruent phylogenetic relationships between viruses suggested genomic recombination. These results have significant implications for parapoxvirus infection biology and virus evolution in nature.

Journal

Archives of VirologySpringer Journals

Published: Jun 1, 2015

References

  • Surveillance of Parapoxvirus among ruminants in Virginia and Connecticut
    Roess, AA; McCollum, AM; Gruszynski, K; Zhao, H; Davidson, W; Lafon, N; Engelmeyer, T; Moyer, B; Godfrey, C; Kilpatrick, H; Labonte, A; Murphy, J; Carroll, DS; Li, Y; Damon, IK

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