Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Stroop (1992)
Studies of interference in serial verbal reactions.Journal of Experimental Psychology: General, 18
C. Lange, A. Seese, S. Schwarzenböck, K. Steinhoff, Bert Umland-Seidler, B. Krause, W. Brenner, O. Sabri, J. Kurth, S. Hesse, R. Buchert (2014)
CT-Based Attenuation Correction in I-123-Ioflupane SPECTPLoS ONE, 9
David Vaillancourt, Daniel Schonfeld, Y. Kwak, N. Bohnen, R. Seidler (2013)
Dopamine overdose hypothesis: Evidence and clinical implicationsMovement Disorders, 28
A. Brück, S. Aalto, E. Nurmi, T. Vahlberg, J. Bergman, J. Rinne (2006)
Striatal subregional 6‐[18F]fluoro‐L‐dopa uptake in early Parkinson's disease: A two‐year follow‐up studyMovement Disorders, 21
J. Rinne, R. Portin, H. Ruottinen, E. Nurmi, J. Bergman, M. Haaparanta, O. Solin (2000)
Cognitive impairment and the brain dopaminergic system in Parkinson disease: [18F]fluorodopa positron emission tomographic study.Archives of neurology, 57 4
J. Darcourt, J. Booij, K. Tatsch, A. Varrone, T. Borght, Ö. Kapucu, K. Någren, F. Nobili, Z. Walker, K. Laere (2010)
EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2European Journal of Nuclear Medicine and Molecular Imaging, 37
F. Fera, G. Nicoletti, A. Cerasa, N. Romeo, O. Gallo, M. Gioia, G. Arabia, P. Pugliese, M. Zappia, A. Quattrone (2007)
Dopaminergic modulation of cognitive interference after pharmacological washout in Parkinson's diseaseBrain Research Bulletin, 74
Leigh Christopher, C. Marras, Sarah Duff-Canning, Y. Koshimori, Robert Chen, I. Boileau, B. Segura, O. Monchi, A. Lang, P. Rusjan, S. Houle, A. Strafella (2014)
Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment.Brain : a journal of neurology, 137 Pt 2
R. Cools, R. Barker, B. Sahakian, T. Robbins (2003)
l-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson’s diseaseNeuropsychologia, 41
E. Aarts, Abraham Nusselein, P. Smittenaar, R. Helmich, B. Bloem, R. Cools (2014)
Greater striatal responses to medication in Parkinson׳s disease are associated with better task-switching but worse reward performanceNeuropsychologia, 62
M. Bullinger (1995)
German translation and psychometric testing of the SF-36 Health Survey: preliminary results from the IQOLA Project. International Quality of Life Assessment.Social science & medicine, 41 10
A. Tziortzi, S. Haber, G. Searle, C. Tsoumpas, C. Long, P. Shotbolt, G. Douaud, S. Jbabdi, Timothy Behrens, E. Rabiner, M. Jenkinson, R. Gunn (2014)
Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.Cerebral cortex, 24 5
V. Kaasinen, J. Rinne (2002)
Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's diseaseNeuroscience & Biobehavioral Reviews, 26
C. Polito, V. Berti, S. Ramat, E. Vanzi, M. Cristofaro, G. Pellicanò, Francesco Mungai, P. Marini, A. Formiconi, S. Sorbi, A. Pupi (2012)
Interaction of caudate dopamine depletion and brain metabolic changes with cognitive dysfunction in early Parkinson's diseaseNeurobiology of Aging, 33
M Bullinger (1995)
German translation and psychometric testing of the SF-36 Health Survey: preliminary results from the IQOLA ProjectInt Qual Life Assess Soc Sci Med, 41
Anna Costa, C. Fougère, O. Pogarell, H. Möller, M. Riedel, U. Ettinger (2013)
Impulsivity is related to striatal dopamine transporter availability in healthy malesPsychiatry Research: Neuroimaging, 211
J. Rinne, R. Portin, H. Ruottinen, E. Nurmi, M. Haaparanta, O. Solin (2015)
Cognitive Impairment and the Brain Dopaminergic System in Parkinson Disease
G. Alexander, M. DeLong, P. Strick (1986)
Parallel organization of functionally segregated circuits linking basal ganglia and cortex.Annual review of neuroscience, 9
J. Booij, P. Kemp (2008)
Dopamine transporter imaging with [123I]FP-CIT SPECT: potential effects of drugsEuropean Journal of Nuclear Medicine and Molecular Imaging, 35
Timothy Behrens, H. Johansen-Berg, M. Woolrich, S. Smith, C. Wheeler-Kingshott, P. Boulby, G. Barker, E. Sillery, K. Sheehan, O. Ciccarelli, A. Thompson, J. Brady, P. Matthews (2003)
Non-invasive mapping of connections between human thalamus and cortex using diffusion imagingNature Neuroscience, 6
Alex MacDonald, O. Monchi, Ken Seergobin, H. Ganjavi, Ruzbeh Tamjeedi, Penny MacDonald (2013)
Parkinson's disease duration determines effect of dopaminergic therapy on ventral striatum functionMovement Disorders, 28
J. Dalrymple-Alford, M. MacAskill, Chris Nakas, L. Livingston, C. Graham, G. Crucian, T. Melzer, J. Kirwan, R. Keenan, S. Wells, R. Porter, R. Watts, T. Anderson (2010)
The MoCANeurology, 75
A. Costa, A. Peppe, I. Mazzù, M. Longarzo, C. Caltagirone, G. Carlesimo (2014)
Dopamine Treatment and Cognitive Functioning in Individuals with Parkinson's Disease: The “Cognitive Flexibility” Hypothesis Seems to WorkBehavioural Neurology, 2014
A. Hughes, S. Daniel, L. Kilford, A. Lees, London Wcln, J. Hughes (1992)
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.Journal of Neurology, Neurosurgery & Psychiatry, 55
K. Chou, A. Lenhart, R. Koeppe, N. Bohnen (2014)
Abnormal MoCA and normal range MMSE scores in Parkinson disease without dementia: cognitive and neurochemical correlates.Parkinsonism & related disorders, 20 10
A. Brück, R. Portin, A. Lindell, A. Laihinen, J. Bergman, M. Haaparanta, O. Solin, J. Rinne (2001)
Positron emission tomography shows that impaired frontal lobe functioning in Parkinson’s disease is related to dopaminergic hypofunction in the caudate nucleusNeuroscience Letters, 311
D. Kupitz, I. Apostolova, C. Lange, G. Ulrich, H. Amthauer, W. Brenner, R. Buchert (2014)
Global scaling for semi-quantitative analysis in FP-CIT SPECTNuklearmedizin, 53
A. Hartmann, W. Rief, A. Hilbert (2011)
Psychometric Properties of the German Version of the Barratt Impulsiveness Scale, Version 11 (Bis–11) for AdolescentsPerceptual and Motor Skills, 112
R. Cools, L. Altamirano, M. D’Esposito (2006)
Reversal learning in Parkinson's disease depends on medication status and outcome valenceNeuropsychologia, 44
M. Hautzinger (1991)
[The Beck Depression Inventory in clinical practice].Der Nervenarzt, 62 11
Thomas Hawk, Dale Zand (2014)
Parallel OrganizationThe Journal of Applied Behavioral Science, 50
R. Buchert, A. Kluge, L. Tossici-Bolt, J. Dickson, M. Bronzel, C. Lange, S. Asenbaum, J. Booij, L. Kapucu, C. Svarer, P. Koulibaly, F. Nobili, M. Pagani, O. Sabri, T. Sera, K. Tatsch, Thierry Borght, Koen Laere, A. Varrone, H. Iida (2016)
Reduction in camera-specific variability in [123I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controlsEuropean Journal of Nuclear Medicine and Molecular Imaging, 43
F. Turkheimer, Catherine Smith, Kathleen Schmidt (2001)
Estimation of the Number of “True” Null Hypotheses in Multivariate Analysis of Neuroimaging DataNeuroImage, 13
JC Dalrymple-Alford, MR MacAskill, CT Nakas, L Livingston, C Graham, GP Crucian, TR Melzer, J Kirwan, R Keenan, S Wells, RJ Porter, R Watts, TJ Anderson (2010)
The MoCA: well-suited screen for cognitive impairment in Parkinson diseaseNeurology, 75
L. Ramani, N. Malek, J. Patterson, T. Nissen, E. Newman (2017)
Relationship between [123I]‐FP‐CIT SPECT and clinical progression in Parkinson's diseaseActa Neurologica Scandinavica, 135
E. Mäkinen, J. Joutsa, Juuso Isotalo, V. Kaasinen (2016)
No relevant midbrain atrophy in Parkinson's diseaseActa Neurologica Scandinavica, 134
S. Kish, K. Shannak, O. Hornykiewicz (1988)
Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications.The New England journal of medicine, 318 14
M. Pellecchia, M. Picillo, Gabriella Santangelo, K. Longo, M. Moccia, Roberto Erro, M. Amboni, C. Vitale, C. Vicidomini, Marco Salvatore, Paolo Barone, S. Pappatà (2015)
Cognitive performances and DAT imaging in early Parkinson's disease with mild cognitive impairment: a preliminary studyActa Neurologica Scandinavica, 131
G. Halliday, J. Leverenz, J. Schneider, C. Adler (2014)
The neurobiological basis of cognitive impairment in Parkinson's diseaseMovement Disorders, 29
F. Siepel, K. Brønnick, J. Booij, B. Ravina, A. Lebedev, J. Pereira, R. Grüner, D. Aarsland (2014)
Cognitive executive impairment and dopaminergic deficits in de novo Parkinson's diseaseMovement Disorders, 29
D. Rajput (1993)
Accuracy of clinical diagnosis of idiopathic Parkinson's disease.Journal of Neurology, Neurosurgery & Psychiatry, 56
T. Robbins, R. Cools (2014)
Cognitive deficits in Parkinson's disease: A cognitive neuroscience perspectiveMovement Disorders, 29
I. Rektorová, H. Srovnalová, R. Kubíková, J. Prášek (2008)
Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's diseaseMovement Disorders, 23
Parkinson’s disease (PD) patients show cognitive deficits that are relevant in terms of prognosis and quality of life. Degeneration of striatal dopaminergic afferents proceeds from dorsal/caudal to anterior/ventral and is discussed to account for some of these symptoms. Treatment with dopamine (DA) has differential effects on cognitive dysfunctions, improving some and worsening others. We hypothesized that cognitive performance during the dopaminergic OFF state correlates with DAT availability in the associative striatum. 16 PD patients underwent motor and cognitive examination ON and OFF DA. Global cognition was measured using the Montréal Cognitive Assessment (MoCA) test and executive functioning using a Stroop test. Nigrostriatal dopaminergic innervation was characterized with [123I]FP-CIT SPECT. A connectivity atlas of the striatum was used to assess DAT availability in functionally defined striatal subregions. Correlations between imaging data and behavioral data OFF medication were calculated. Correlations between DAT availability and MoCA performance in the dopaminergic OFF state was strongest in the associative part of the striatum (r = 0.674, p = 0.004). MoCA test performance did not differ between the ON and the OFF state. There was no correlation of DAT availability with Stroop performance in the OFF state but performance was significantly better during the ON state. Not only motor but also cognitive dysfunctions in PD are associated with striatal dopaminergic depletion. Cognitive decline in non-demented PD patients goes along with nigrostriatal degeneration, most pronounced in the associative subdivision of the striatum. In addition, the present findings suggest that executive dysfunctions are ameliorated by DA whereas global cognition is not improved by dopaminergic medication.
Journal of Neural Transmission – Springer Journals
Published: Jun 22, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.