Journal of Neurology (2018) 265:1706–1707 https://doi.org/10.1007/s00415-018-8914-8 LE T TER TO THE EDITORS 1 1 Sergio Della Sala · Robert D. McIntosh Received: 17 May 2018 / Accepted: 18 May 2018 / Published online: 29 May 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Dear Sirs, By definition, 40% of people score at or below the 40th percentile on any task. Using this threshold for impairment, A recent high-profile paper in JAMA reported on a case- and without any correction for the number of test scores series with neurological and cognitive symptoms due to examined (37 tests*6 people = 222), we should expect an undetermined cause . Under study were US govern- around 89 false positives. We ran a simulation to explore the ment personnel who had been working in Havana, and had range of outcomes, using the authors’ system for counting reported auditory and sensory phenomena of unknown ori- impairments. Our method was to substitute their test scores gin. Six of the 21 people in the study were assessed with a with random numbers from a uniform distribution between neuropsychological battery of 37 tests divided into 10 cog- 1 and 100, and to count how many people showed at least
Journal of Neurology – Springer Journals
Published: May 29, 2018
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