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Cognitive impairments that everybody has

Cognitive impairments that everybody has Journal of Neurology (2018) 265:1706–1707 https://doi.org/10.1007/s00415-018-8914-8 LE T TER TO  THE   EDITORS 1 1 Sergio Della Sala  · Robert D. McIntosh Received: 17 May 2018 / Accepted: 18 May 2018 / Published online: 29 May 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Dear Sirs, By definition, 40% of people score at or below the 40th percentile on any task. Using this threshold for impairment, A recent high-profile paper in JAMA reported on a case- and without any correction for the number of test scores series with neurological and cognitive symptoms due to examined (37 tests*6 people = 222), we should expect an undetermined cause [1]. Under study were US govern- around 89 false positives. We ran a simulation to explore the ment personnel who had been working in Havana, and had range of outcomes, using the authors’ system for counting reported auditory and sensory phenomena of unknown ori- impairments. Our method was to substitute their test scores gin. Six of the 21 people in the study were assessed with a with random numbers from a uniform distribution between neuropsychological battery of 37 tests divided into 10 cog- 1 and 100, and to count how many people showed at least http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurology Springer Journals

Cognitive impairments that everybody has

Della Sala, Sergio; McIntosh, Robert
Journal of Neurology , Volume 265 (7) – May 29, 2018
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Neurology; Neurosciences; Neuroradiology
ISSN
0340-5354
eISSN
1432-1459
DOI
10.1007/s00415-018-8914-8
Publisher site
See Article on Publisher Site

Abstract

Journal of Neurology (2018) 265:1706–1707 https://doi.org/10.1007/s00415-018-8914-8 LE T TER TO  THE   EDITORS 1 1 Sergio Della Sala  · Robert D. McIntosh Received: 17 May 2018 / Accepted: 18 May 2018 / Published online: 29 May 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Dear Sirs, By definition, 40% of people score at or below the 40th percentile on any task. Using this threshold for impairment, A recent high-profile paper in JAMA reported on a case- and without any correction for the number of test scores series with neurological and cognitive symptoms due to examined (37 tests*6 people = 222), we should expect an undetermined cause [1]. Under study were US govern- around 89 false positives. We ran a simulation to explore the ment personnel who had been working in Havana, and had range of outcomes, using the authors’ system for counting reported auditory and sensory phenomena of unknown ori- impairments. Our method was to substitute their test scores gin. Six of the 21 people in the study were assessed with a with random numbers from a uniform distribution between neuropsychological battery of 37 tests divided into 10 cog- 1 and 100, and to count how many people showed at least

Journal

Journal of Neurology – Springer Journals

Published: May 29, 2018

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