Cognitive effects of bilateral high frequency repetitive transcranial magnetic stimulation in early phase psychosis: a pilot study

Cognitive effects of bilateral high frequency repetitive transcranial magnetic stimulation in... Cognitive dysfunction is a core facet of schizophrenia that is present early in the course of the illness and contributes to diminished functioning and outcomes. Repetitive transcranial magnetic stimulation (rTMS) is a relatively new neuropsychiatric intervention. Initially used in treatment resistant depression, investigators are now studying rTMS for other psychiatric diseases such as schizophrenia. In this study we examined the effect of high frequency rTMS on cognitive function in a group of individuals with early phase psychosis. Twenty subjects were randomized (1:1) in double-blind fashion to rTMS or sham condition. Over two weeks subjects underwent ten sessions of high frequency, bilateral, sequential rTMS targeting the dorsolateral prefrontal cortex (DLPFC). Prior to beginning and following completion of study treatment, subjects completed a cognitive assessment and magnetic resonance imaging. Subjects receiving rTMS, compared to sham treatment, displayed improvement on a standardized cognitive battery both immediately following the course of study treatment and at follow-up two weeks later. Imaging results revealed that left frontal cortical thickness at baseline was correlated with treatment response. The study treatment was found to be safe and well tolerated. These results suggest that rTMS may hold promise for the treatment of cognitive dysfunction in the early phase of psychosis, and that MRI may provide biomarkers predicting response to the treatment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Imaging and Behavior Springer Journals

Cognitive effects of bilateral high frequency repetitive transcranial magnetic stimulation in early phase psychosis: a pilot study

Download PDF
10 pages
Read Article

Loading next page...
 
/lp/springer_journal/cognitive-effects-of-bilateral-high-frequency-repetitive-transcranial-FLceiaekjn
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Neurosciences; Neuroradiology; Neuropsychology; Psychiatry
ISSN
1931-7557
eISSN
1931-7565
DOI
10.1007/s11682-018-9902-4
Publisher site
See Article on Publisher Site

Abstract

Cognitive dysfunction is a core facet of schizophrenia that is present early in the course of the illness and contributes to diminished functioning and outcomes. Repetitive transcranial magnetic stimulation (rTMS) is a relatively new neuropsychiatric intervention. Initially used in treatment resistant depression, investigators are now studying rTMS for other psychiatric diseases such as schizophrenia. In this study we examined the effect of high frequency rTMS on cognitive function in a group of individuals with early phase psychosis. Twenty subjects were randomized (1:1) in double-blind fashion to rTMS or sham condition. Over two weeks subjects underwent ten sessions of high frequency, bilateral, sequential rTMS targeting the dorsolateral prefrontal cortex (DLPFC). Prior to beginning and following completion of study treatment, subjects completed a cognitive assessment and magnetic resonance imaging. Subjects receiving rTMS, compared to sham treatment, displayed improvement on a standardized cognitive battery both immediately following the course of study treatment and at follow-up two weeks later. Imaging results revealed that left frontal cortical thickness at baseline was correlated with treatment response. The study treatment was found to be safe and well tolerated. These results suggest that rTMS may hold promise for the treatment of cognitive dysfunction in the early phase of psychosis, and that MRI may provide biomarkers predicting response to the treatment.

Journal

Brain Imaging and Behavior – Springer Journals

Published: May 31, 2018

References

  • Moderate effects of noninvasive brain stimulation of the frontal cortex for improving negative symptoms in schizophrenia: Meta-analysis of controlled trials
    Aleman, A; Enriquez-Geppert, S; Knegtering, H; Dlabac-de Lange, JJ
  • Non-invasive magnetic stimulation of human motor cortex
    Baker, AT; Freeston, IL
  • Cognition in schizophrenia: Core psychological and neural mechanisms
    Barch, DM; Ceaser, A
  • Can repetitive magnetic stimulation improve cognition in schizophrenia? Pilot data from a randomized controlled trial
    Barr, MS; Farzan, F; Rajji, TK; Voineskos, AN; Blumberger, DM; Arenovich, T
  • Safety of different inter-train intervals for repetitive transcranial magnetic stimulation and recommendations for safe ranges of stimulation parameters
    Chen, R; Gerloff, C; Classen, J; Wassermann, EM; Hallett, M; Cohen, LG
  • Repetitive transcranial magnetic stimulation in the treatment of chronic negative schizophrenia: A pilot study
    Cohen, E; Bernardo, M; Masana, J; Arrufat, FJ; Navarro, V; Valls, S
  • Transcranial magnetic stimulation of left auditory cortex in patients with schizophrenia: Effects on hallucinations and neurocognition
    d'Alfonso, AA; Aleman, A; Kessels, RP; Schouten, EA; Postma, A; Linden, JA; Kahn, RS
  • Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature
    Destrieux, C; Fischl, B; Dale, A; Halgren, E
  • Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments
    Fitzgerald, PB; Maller, JJ; Hoy, KE; Thomson, R; Daskalakis, ZJ
  • A preliminary fMRI study of the effects on cortical activation of the treatment of refractory auditory hallucinations with rTMS
    Fitzgerald, PB; Sritharan, A; Benitez, J; Daskalakis, ZJ; Jackson, G; Kulkarni, J; Egan, GF
  • Correlates of cognitive impairment in first episode schizophrenia: The EUFEST study
    Galderisi, S; Davidson, M; Kahn, RS; Mucci, A; Boter, H; Gheorghe, MD
  • International consensus study of antipsychotic dosing
    Gardner, DM; Murphy, AL; O'Donnell, H; Centorrino, F; Baldessarini, RJ
  • Longitudinal studies of cognition and functional outcome in schizophrenia: Implications for MATRICS
    Green, MF; Kern, RS; Heaton, RK
  • Transcranial magnetic stimulation and the human brain
    Hallett, M
  • Cognition in schizophrenia
    Harvey, PD; Bowie, CR; Friedman, JI
  • Cognitive effects of high-frequency rTMS in schizophrenia patients with predominant negative symptoms: Results from a multicenter randomized sham-controlled trial
    Hasan, A; Guse, B; Cordes, J; Wolwer, W; Winterer, G; Gaebel, W; Wobrock, T
  • Repetitive noninvasive brain stimulation to modulate cognitive functions in schizophrenia: A systematic review of primary and secondary outcomes
    Hasan, A; Strube, W; Palm, U; Wobrock, T
  • Structural brain changes are associated with response of negative symptoms to prefrontal repetitive transcranial magnetic stimulation in patients with schizophrenia
    Hasan, A; Wobrock, T; Guse, B; Langguth, B; Landgrebe, M; Eichhammer, P
  • Temporoparietal transcranial magnetic stimulation for auditory hallucinations: Safety, efficacy and moderators in a fifty patient sample
    Hoffman, RE; Gueorguieva, R; Hawkins, KA; Varanko, M; Boutros, NN; Wu, YT
  • Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations
    Hoffman, RE; Hawkins, KA; Gueorguieva, R; Boutros, NN; Rachid, F; Carroll, K; Krystal, JH
  • Physiology of repetitive transcranial magnetic stimulation of the human brain
    Hoogendam, JM; Ramakers, GM; Lazzaro, V
  • Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: A systematic review and meta-analysis
    Hsu, WY; Ku, Y; Zanto, TP; Gazzaley, A
  • Emerging roles of metaplasticity in behaviour and disease
    Hulme, SR; Jones, OD; Abraham, WC
  • The brief assessment of cognition in schizophrenia: Reliability, sensitivity, and comparison with a standard neurocognitive battery
    Keefe, RS; Goldberg, TE; Harvey, PD; Gold, JM; Poe, MP; Coughenour, L
  • Norms and standardization of the brief assessment of cognition in schizophrenia (BACS)
    Keefe, RS; Harvey, PD; Goldberg, TE; Gold, JM; Walker, TM; Kennel, C; Hawkins, K
  • Deep transcranial magnetic stimulation add-on for treatment of negative symptoms and cognitive deficits of schizophrenia: A feasibility study
    Levkovitz, Y; Rabany, L; Harel, EV; Zangen, A
  • Transcranial magnetic stimulation for auditory hallucinations in schizophrenia
    McIntosh, AM; Semple, D; Tasker, K; Harrison, LK; Owens, DG; Johnstone, EC; Ebmeier, KP
  • Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia
    Minzenberg, MJ; Laird, AR; Thelen, S; Carter, CS; Glahn, DC
  • The tolerability of rTMS treatment in schizophrenia with respect to cognitive function
    Mittrach, M; Thunker, J; Winterer, G; Agelink, MW; Regenbrecht, G; Arends, M
  • Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: A randomized controlled pilot study
    Mogg, A; Purvis, R; Eranti, S; Contell, F; Taylor, JP; Nicholson, T; McLoughlin, DM
  • The double-blind sham-controlled study of high-frequency rTMS (20 Hz) for negative symptoms in schizophrenia: Negative results
    Novak, T; Horacek, J; Mohr, P; Kopecek, M; Skrdlantova, L; Klirova, M
  • Does repetitive transcranial magnetic stimulation have a positive effect on working memory and neuronal activation in treatment of negative symptoms of schizophrenia?
    Prikryl, R; Mikl, M; Prikrylova Kucerova, H; Ustohal, L; Kasparek, T; Marecek, R; Vanicek, J
  • High frequency repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in schizophrenic patients
    Rollnik, JD; Huber, TJ; Mogk, H; Siggelkow, S; Kropp, S; Dengler, R
  • Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research
    Rossi, S; Hallett, M; Rossini, PM; Pascual-Leone, A
  • Repetitive transcranial magnetic stimulation (rTMS) as an augmentation treatment for the negative symptoms of schizophrenia: A 4-week randomized placebo controlled study
    Schneider, AL; Schneider, TL; Stark, H
  • Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis
    Shi, C; Yu, X; Cheung, EF; Shum, DH; Chan, RC
  • Transcranial magnetic stimulation: New insights into representational cortical plasticity
    Siebner, HR; Rothwell, J
  • Meta-analysis of repetitive transcranial magnetic stimulation in the treatment of auditory verbal hallucinations: Update and effects after one month
    Slotema, CW; Aleman, A; Daskalakis, ZJ; Sommer, IE
  • Should we expand the toolbox of psychiatric treatment methods to include repetitive transcranial magnetic stimulation (rTMS)?
    Slotema, CW; Blom, JD; Hoek, HW; Sommer, IE
  • Review of the efficacy of transcranial magnetic stimulation for auditory verbal hallucinations
    Slotema, CW; Blom, JD; Lutterveld, R; Hoek, HW; Sommer, IE
  • Cognitive deficits in recent-onset and chronic schizophrenia
    Sponheim, SR; Jung, RE; Seidman, LJ; Mesholam-Gately, RI; Manoach, DS; O'Leary, DS
  • Enhancing memory performance with rTMS in healthy subjects and individuals with mild cognitive impairment: The role of the right dorsolateral prefrontal cortex
    Turriziani, P; Smirni, D; Zappala, G; Mangano, GR; Oliveri, M; Cipolotti, L
  • Functional connectivity of the temporo-parietal region in schizophrenia: Effects of rTMS treatment of auditory hallucinations
    Vercammen, A; Knegtering, H; Liemburg, EJ; Boer, JA; Aleman, A
  • Risk and safety of repetitive transcranial magnetic stimulation: Report and suggested guidelines from the international workshop on the safety of repetitive transcranial magnetic stimulation, June 5-7, 1996
    Wassermann, EM
  • Repetitive transcranial magnetic stimulation (rTMS) improves facial affect recognition in schizophrenia
    Wolwer, W; Lowe, A; Brinkmeyer, J; Streit, M; Habakuck, M; Agelink, MW
  • Consensus: Motor cortex plasticity protocols
    Ziemann, U; Paulus, W; Nitsche, MA; Pascual-Leone, A; Byblow, WD; Berardelli, A
  • Modifying motor learning through gating and homeostatic metaplasticity
    Ziemann, U; Siebner, HR

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial