Codon usage bias in herpesvirus

Codon usage bias in herpesvirus In this study, I present a comprehensive analysis of codon usage bias in 43 herpesviruses for which the whole genome has been sequenced. The values of the effective number of codons revealed that the majority of the herpesviruses did not have high codon bias, with the exceptions of only simplexviruses and some varicelloviruses. The results of correspondence analysis, a plot of ENC and GC content at the third position of the codon and analysis of preferred codons all revealed that the codon bias was mainly influenced by nucleotide composition. This suggests that mutation pressure is the main factor influencing codon usage bias in herpesviruses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Codon usage bias in herpesvirus

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Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-010-0597-0
Publisher site
See Article on Publisher Site

Abstract

In this study, I present a comprehensive analysis of codon usage bias in 43 herpesviruses for which the whole genome has been sequenced. The values of the effective number of codons revealed that the majority of the herpesviruses did not have high codon bias, with the exceptions of only simplexviruses and some varicelloviruses. The results of correspondence analysis, a plot of ENC and GC content at the third position of the codon and analysis of preferred codons all revealed that the codon bias was mainly influenced by nucleotide composition. This suggests that mutation pressure is the main factor influencing codon usage bias in herpesviruses.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2010

References

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