Co-exposure to an Aryl Hydrocarbon Receptor Endogenous Ligand, 6-Formylindolo[3,2-b]carbazole (FICZ), and Cadmium Induces Cardiovascular Developmental Abnormalities in Mice

Co-exposure to an Aryl Hydrocarbon Receptor Endogenous Ligand, 6-Formylindolo[3,2-b]carbazole... 6-Formylindolo[3,2-b]carbazole (FICZ) is a signal substance and an endogenous activator of aryl hydrocarbon receptor (AHR). Cadmium (Cd) is an environmental pollutant that can activate both AHR and Wnt/β-catenin signaling pathways. We aimed to determine how dysregulated signaling through AHR-Wnt/β-catenin cross-talk can influence mice heart development. Mice fetuses were exposed to Cd alone or in combination with FICZ in gestation day (GD) 0. In GD18, fetuses were harvested and randomly divided into two parts for stereological and molecular studies. Stereological and tessellation results revealed that when fetuses were co-exposed with FICZ and Cd, abnormalities were synergistically raised. In the presence of FICZ, mRNA expres- sion levels of Wnt/β-catenin target genes significantly enhanced, especially when animals co-treated with FICZ and Cd. Based on these findings, we propose that chemical pollutants can interfere with the normal function of AHR that has a physiological role in regulating Wnt/β-catenin during cardiogenesis. . . . . Keywords Aryl hydrocarbon receptor Wnt/β-catenin FICZ Cadmium Cardiogenesis Introduction The aryl hydrocarbon receptor (AHR) is a cytosolic ligand- activated protein that has been shown to be activated and According to the Barker’s approach, early life defects, espe- expressed in many tissues during embryonic development [3]. cially during the embryonic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Trace Element Research Springer Journals

Co-exposure to an Aryl Hydrocarbon Receptor Endogenous Ligand, 6-Formylindolo[3,2-b]carbazole (FICZ), and Cadmium Induces Cardiovascular Developmental Abnormalities in Mice

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Life Sciences; Biochemistry, general; Biotechnology; Nutrition; Oncology
ISSN
0163-4984
eISSN
1559-0720
D.O.I.
10.1007/s12011-018-1391-1
Publisher site
See Article on Publisher Site

Abstract

6-Formylindolo[3,2-b]carbazole (FICZ) is a signal substance and an endogenous activator of aryl hydrocarbon receptor (AHR). Cadmium (Cd) is an environmental pollutant that can activate both AHR and Wnt/β-catenin signaling pathways. We aimed to determine how dysregulated signaling through AHR-Wnt/β-catenin cross-talk can influence mice heart development. Mice fetuses were exposed to Cd alone or in combination with FICZ in gestation day (GD) 0. In GD18, fetuses were harvested and randomly divided into two parts for stereological and molecular studies. Stereological and tessellation results revealed that when fetuses were co-exposed with FICZ and Cd, abnormalities were synergistically raised. In the presence of FICZ, mRNA expres- sion levels of Wnt/β-catenin target genes significantly enhanced, especially when animals co-treated with FICZ and Cd. Based on these findings, we propose that chemical pollutants can interfere with the normal function of AHR that has a physiological role in regulating Wnt/β-catenin during cardiogenesis. . . . . Keywords Aryl hydrocarbon receptor Wnt/β-catenin FICZ Cadmium Cardiogenesis Introduction The aryl hydrocarbon receptor (AHR) is a cytosolic ligand- activated protein that has been shown to be activated and According to the Barker’s approach, early life defects, espe- expressed in many tissues during embryonic development [3]. cially during the embryonic

Journal

Biological Trace Element ResearchSpringer Journals

Published: May 28, 2018

References

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