Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes

Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes Recently, the incidence of myocardial infarction has been increasing annually. Now cell therapy is a major new strategy in the treatment of this public health challenge. Most recently, evidences showed that MSCs can reduce the area of infarction and improve the heart function. In our study we found that MSCs could promote cardiomyocytes proliferation, inhibit the apoptosis of cardiomyocytes and promote cardiomyocytes autophagy function. These functions could be a therapeutic effect on myocardial infarction. At the same time, we first revealed that MSCs may achieve these functions by the activation of VEGF signaling pathways. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cytotechnology Springer Journals

Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes

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Publisher
Springer Netherlands
Copyright
Copyright © 2018 by Springer Science+Business Media B.V., part of Springer Nature
Subject
Chemistry; Biotechnology; Biomedicine, general; Biochemistry, general
ISSN
0920-9069
eISSN
1573-0778
D.O.I.
10.1007/s10616-018-0188-6
Publisher site
See Article on Publisher Site

Abstract

Recently, the incidence of myocardial infarction has been increasing annually. Now cell therapy is a major new strategy in the treatment of this public health challenge. Most recently, evidences showed that MSCs can reduce the area of infarction and improve the heart function. In our study we found that MSCs could promote cardiomyocytes proliferation, inhibit the apoptosis of cardiomyocytes and promote cardiomyocytes autophagy function. These functions could be a therapeutic effect on myocardial infarction. At the same time, we first revealed that MSCs may achieve these functions by the activation of VEGF signaling pathways.

Journal

CytotechnologySpringer Journals

Published: Jan 25, 2018

References

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