The aim of this paper is to present a database of isolated communities (CENISO) with high prevalence of genetic disorders or congenital anomalies in Brazil. We used two strategies to identify such communities: (1) a systematic literature review and (2) a Brumor strategy^ based on anecdotal accounts. All rumors and reports were validated in a stepwise process. The bibliographical search identified 34 rumors and 245 rumors through the rumor strategy, and 144 were confirmed. A database like this one presented here represents an important tool for the planning of health priorities for rare diseases in low- and middle-income countries with large populations. . . . . Keywords Genetic isolates Rumors Endogamy Congenital anomalies Rare diseases Introduction Wakefield 2001). There are a variety of populations around the world with a high prevalence of either Mendelian Genetic isolates (monogenic) disorders or oligogenic diseases dominated by the effects of a major gene. These disease clusters can be due A disease cluster can be defined as an area and/or period of time to geographical, cultural, religious, or even linguistic isolation where the prevalence of a particular disease is high, that is, (Zlotogora 2007). where the number of cases exceeds expectations (Elliot and In
Journal of Community Genetics – Springer Journals
Published: Jun 2, 2018
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