Acta Neuropathologica (2018) 135:307–310 https://doi.org/10.1007/s00401-018-1816-0 EDITORIAL Britta Engelhardt Published online: 3 February 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Cutting edge in vivo imaging technologies have become localized in choroid plexus epithelium have long been in central in advancing our understanding of the structure and the focus of research in physiology and pharmacology and function of the central nervous system (CNS) in preclinical more recently also the fields of developmental biology, vas - research and also in clinical diagnostics. Investigation of cular biology and neuroimmunology. Thus, many excellent fluid movements and immune cell trafficking within the CNS scholarly reviews have been published summarizing bar- in experimental animals by two-photon microscopy has chal- rier characteristics of the BBB and BCSFB with either a lenged previous views on the movement of interstitial fluid focus on development or on their cellular junctions or on (ISF) and cerebrospinal fluid (CSF) within the CNS [ 10] as expression of transporters and efflux pumps in the context well as the concept of the CNS immune privilege . In the of drug delivery or in the context of their potential immune clinic, faster acquisitions and the development of advanced functions. Within this Cluster on Barriers
Acta Neuropathologica – Springer Journals
Published: Feb 3, 2018
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