Mammalian Genome 9, 253-255 (1998). Mammalian GIworn Imu.VUrolinN 11— I:,.n © Springer-Verlag New York Inc. 1998 Close linkage of p130 and Ftl is conserved among mammals Ralf Lesche, Ulrich Wither Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany Received: 1 September 1997 / Accepted: 7 November 1997 The retinoblastoma-related family of proteins, also called pocket proteins, comprises pRb and the related proteins p107 and p130 (for reviews see Whyte 1995; Paggi et al. 1996). Common to all pocket protein family members is their inhibitory effect upon cell cycle progression. However, distinct mechanisms for the growth- suppressive function of the individual pocket protein members have been reported (Whyte 1995). p130 was shown to be the main regulator of the transcription factors E2F-4/5 in G o, and early G 1 , phase of the cell cycle (Cobrinik et al. 1993; Vairo et al. 1995; Hijmans et al. 1995). These and other studies suggest a key func- tion for p130 in the regulation of Go/G 1 transition and during cellular differentiation (for a review, Sidle et al. 1996). The control of p130 activity is well studied on the level of protein modifica- Fig. 1. Linkage of p130 and Ftl in mammals.
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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