Clopidogrel

Clopidogrel Reactions 1704, p114 - 2 Jun 2018 Ischaemic stroke and subdural haematoma: case report In a retrospective observational study involving 72 patients, a patient [age and sex not stated] was described, who developed ischaemic stroke and subdural haematoma following treatment with clopidogrel for myocardial infarction prophylaxis [route, dosage and outcome not stated; not all time to reaction onsets stated]. The patient had a 12 year history of myocardial infarction. The patient developed a subdural intracranial haemorrhage and was scheduled for craniotomy. Prior to the surgery, the patient had received a secondary myocardial infarction prophylaxis with clopidogrel. One day following the surgery, post-operative CT scan showed an increased size of the subdural haematoma. On day 12 following the surgery and clopidogrel discontinuation, the patient developed an ischaemic stroke. The patient’s clopidogrel therapy was not resumed and the ischaemic stroke was considered secondary to the prolonged clopidogrel discontinuation. Author comment: "Only one arterial thrombotic event occurred. The ischaemic stroke occurred 12 days after discontinuation of clopidogrel." "Recurrent [intracranial haemorrhage] occurred more often in patients receiving clopidogrel before surgery." Baschin M, et al. Platelet transfusion to reverse antiplatelet therapy before decompressive surgery in patients with intracranial haemorrhage. Vox Sanguinis 112: 535-541, No. 6, Aug 2017. Available from: URL: http://doi.org/10.1111/ vox.12542 - Germany 803322960 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Clopidogrel

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46757-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p114 - 2 Jun 2018 Ischaemic stroke and subdural haematoma: case report In a retrospective observational study involving 72 patients, a patient [age and sex not stated] was described, who developed ischaemic stroke and subdural haematoma following treatment with clopidogrel for myocardial infarction prophylaxis [route, dosage and outcome not stated; not all time to reaction onsets stated]. The patient had a 12 year history of myocardial infarction. The patient developed a subdural intracranial haemorrhage and was scheduled for craniotomy. Prior to the surgery, the patient had received a secondary myocardial infarction prophylaxis with clopidogrel. One day following the surgery, post-operative CT scan showed an increased size of the subdural haematoma. On day 12 following the surgery and clopidogrel discontinuation, the patient developed an ischaemic stroke. The patient’s clopidogrel therapy was not resumed and the ischaemic stroke was considered secondary to the prolonged clopidogrel discontinuation. Author comment: "Only one arterial thrombotic event occurred. The ischaemic stroke occurred 12 days after discontinuation of clopidogrel." "Recurrent [intracranial haemorrhage] occurred more often in patients receiving clopidogrel before surgery." Baschin M, et al. Platelet transfusion to reverse antiplatelet therapy before decompressive surgery in patients with intracranial haemorrhage. Vox Sanguinis 112: 535-541, No. 6, Aug 2017. Available from: URL: http://doi.org/10.1111/ vox.12542 - Germany 803322960 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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